Sugiyama Kazutoshi, Sano Ayako, Murakami Masaru, Ogawa Takashi, Mishima Hiroyuki, Otake Hiroyuki, Kamei Katsuhiko, Sugiyama Shuniti
Sugiyama Veterinary Clinic, Shizuoka, Japan.
Med Mycol. 2008 Aug;46(5):505-10. doi: 10.1080/13693780801968555. Epub 2008 Mar 10.
Chaetomium globosum is commonly found in natural environments worldwide and is known to be a causative agent for emerging fungal infections. The present study describes a case of erythematous epilation of a dog caused by C. globosum. A mixed-breed young dog, a 4-months-old male, weighing 7.25 kg, showed depilation, scales, and dermatitis with slightly itchiness on his skin. The main symptom was an erythematous epilation on the left subocular skin 7.5 cm in diameter, accompanied by elephantiasis-like hyperplasia and scales. Similar lesions were observed on the skin on both sides of the ear lobes, the heels, tail, and left angulus oris. The scales from the crusted lesion were cultured on chrolamphenicole-added potato dextrose agar plates at the first visit, as well as followed by ambulatory practices. The isolates at the first visit, 1 and 3 weeks after treatment, were identified as C. globosum by mycological study and the D1/D2 domain of the large subunit rRNA gene sequence. The patient dog was treated by ketoconzole both orally and externally. The lesions were cured, showing new hair growth 9 weeks later. In addition, the susceptibilities to antifungal agents for the present C. globosum isolate were as follows: amphotericin B, 4.0 microg/ml; 5-FC 64.0 microg/ml; itraconazole, 0.5 microg/ml; miconazole, 1.0 microg/ml; fulconazole, 16.0 microg/ml; ketoconazole, 0.25 microg/ml; and micafungin, 16.0 microg/ml.
球毛壳菌在世界各地的自然环境中普遍存在，并且已知是新兴真菌感染的病原体。本研究描述了一例由球毛壳菌引起的犬红斑脱毛病例。一只4个月大、体重7.25千克的混种幼犬，皮肤出现脱毛、鳞屑和皮炎，伴有轻微瘙痒。主要症状是左眼皮下直径7.5厘米的红斑脱毛，伴有象皮肿样增生和鳞屑。在耳垂两侧、脚跟、尾巴和左口角的皮肤上也观察到类似病变。首次就诊时，将结痂病变处的鳞屑接种在添加氯霉素的马铃薯葡萄糖琼脂平板上培养，并进行门诊观察。首次就诊时、治疗后1周和3周分离得到的菌株，经真菌学研究和大亚基rRNA基因序列的D1/D2结构域鉴定为球毛壳菌。患病犬口服和外用酮康唑进行治疗。9周后病变治愈，有新毛长出。此外，本次分离的球毛壳菌对以下抗真菌药物的敏感性如下：两性霉素B，4.0微克/毫升；5-氟胞嘧啶，64.0微克/毫升；伊曲康唑，0.5微克/毫升；咪康唑，1.0微克/毫升；氟康唑，16.0微克/毫升；酮康唑，0.25微克/毫升；米卡芬净，16.0微克/毫升。
