Hamal Petr, Ostransky Jiri, Dendis Milos, Horváth Radek, Ruzicka Filip, Buchta Vladimir, Vejsova Marcela, Sauer Pavel, Hejnar Petr, Raclavsky Vladislav
Department of Microbiology, University Hospital and Faculty of Medicine, Palacky University Olomouc, Czech Republic.
Med Mycol. 2008 Sep;46(6):601-5. doi: 10.1080/13693780802078180.
Pichia fabianii, a yeast rarely causing human infections, was isolated from the blood of a patient with aortic valve endocarditis. The isolates were initially identified biochemically as Candida pelliculosa, but based on direct sequencing of the ITS2 region of rRNA, they were subsequently reidentified as P. fabianii. Antifungal therapy with fluconazole and later with voriconazole led to the development of resistant variants which had high MIC values to both antifungals. Strong biofilm formation by this yeast could also have played a role in the development of its resistance and allowed for its persistence on the infected valve during antifungal therapy. To our knowledge, this is the first published case of endocarditis and the fourth human infection caused by this yeast species.
法比安毕赤酵母是一种很少引起人类感染的酵母菌，从一名患有主动脉瓣心内膜炎患者的血液中分离得到。最初通过生化方法将分离菌株鉴定为膜醭假丝酵母，但基于rRNA ITS2区域的直接测序，随后将其重新鉴定为法比安毕赤酵母。使用氟康唑以及后来使用伏立康唑进行抗真菌治疗导致产生了对两种抗真菌药物均具有高MIC值的耐药变体。这种酵母菌形成强大的生物膜也可能在其耐药性的产生中起作用，并使其在抗真菌治疗期间能够持续存在于受感染的瓣膜上。据我们所知，这是该酵母菌引起的心内膜炎的首例报道病例，也是该酵母菌引起的第四例人类感染病例。
