Bargagli Elena, Bianchi Nicola, Margollicci Maria, Olivieri Carmela, Luddi Alice, Coviello Giuseppe, Grosso Salvatore, Rottoli Paola
Department of Clinical Medicine and Immunology, Respiratory Diseases Section, Siena University, Italy.
Scand J Clin Lab Invest. 2008;68(6):479-83. doi: 10.1080/00365510701854975.
Sarcoidosis is a multisystemic granulomatous disease with an unpredictable clinical course characterized by accumulation of activated proliferating T lymphocytes and mononuclear phagocytes in affected organs.
The aims of this study were to describe the clinical, radiological and immunological features of a population of sarcoidosis patients followed at the Sarcoidosis Regional Centre in Siena and to analyse chitotriosidase and sIL-2R concentrations in serum of these patients in order to understand their potential as disease markers.
Chitotriosidase and sIL-2R concentrations in serum of sarcoidosis patients were found to be significantly higher than in healthy controls (p<0.01) and a positive correlation between the two markers was documented for the first time. Moreover, chitotriosidase and sIL-2R were expressed differently in different radiographic stages of the disease.
Chitotriosidase and sIL-2R are two markers of sarcoidosis of different origin, the values of which show a correlation in these patients; they are easily detectable in serum and could be useful clinical markers of progression.
结节病是一种多系统肉芽肿性疾病，临床病程不可预测，其特征是受累器官中活化增殖的T淋巴细胞和单核吞噬细胞聚集。
本研究的目的是描述在锡耶纳结节病区域中心随访的一组结节病患者的临床、放射学和免疫学特征，并分析这些患者血清中的几丁质酶和可溶性白细胞介素-2受体（sIL-2R）浓度，以了解它们作为疾病标志物的潜力。
发现结节病患者血清中的几丁质酶和sIL-2R浓度显著高于健康对照组（p<0.01），并且首次记录到这两种标志物之间存在正相关。此外，几丁质酶和sIL-2R在疾病的不同放射学阶段表达不同。
几丁质酶和sIL-2R是两种来源不同的结节病标志物，在这些患者中其值呈现相关性；它们在血清中易于检测，可能是有用的疾病进展临床标志物。
