对耶氏肺孢子菌携带者进行抗磷脂抗体检测。

Antiphospholipid antibodies investigation in Pneumocystis jirovecii carriers.

作者信息

Atienza Maria R, Respaldiza Nieves, De La Santa Eva, Martín-Garrido Isabel, Medrano Francisco J, Varela José M, Calderón Enrique

机构信息

Internal Medicine Service, CIBER de Epidemiología y Salud Pública, Hospital Virgen del Rocío, Sevilla, Spain.

出版信息

Scand J Infect Dis. 2008;40(10):840-2. doi: 10.1080/00365540802179691.

DOI:10.1080/00365540802179691

PMID:18609205

Abstract

It is well documented that antiphospholipid antibodies are increased in patients with HIV-1 infection and these are most commonly seen in those with Pneumocystis jirovecii pneumonia. Therefore it has been proposed that this could be the cause of its presence. Recently, P. jirovecii subclinical infection has been described in non-immunodeficient patients. We report here our experience concerning the possible relationship between P. jirovecii infection in non-immunocompromized adults and the production of antiphospholipid antibodies. Circulating lupus anticoagulant and IgM anticardiolipin antibodies were negative in all patients. IgG anticardiolipin antibodies were positive in 2 out of 5 (40%) P. jirovecii carriers and 2 out of 10 (20%) subjects with no evidence of pulmonary infection by this microorganism (p=0.4).

摘要

有充分文献记载，HIV-1感染患者体内抗磷脂抗体水平升高，且这些抗体最常见于患有耶氏肺孢子菌肺炎的患者。因此，有人提出这可能是其存在的原因。最近，在非免疫缺陷患者中也描述了耶氏肺孢子菌亚临床感染。我们在此报告我们关于非免疫功能低下成年人耶氏肺孢子菌感染与抗磷脂抗体产生之间可能关系的经验。所有患者的循环狼疮抗凝物和IgM抗心磷脂抗体均为阴性。5名耶氏肺孢子菌携带者中有2名（40%）IgG抗心磷脂抗体呈阳性，10名无该微生物肺部感染证据的受试者中有2名（20%）呈阳性（p = 0.4）。