Powell D M, Rodeheaver G T, Foresman P A, Hankins C L, Bellian K T, Zimmer C A, Becker D G, Edlich R F
Department of Plastic Surgery, University of Virginia School of Medicine, Charlottesville.
J Emerg Med. 1991 Jul-Aug;9(4):205-9. doi: 10.1016/0736-4679(91)90414-b.
EMLA is a new topical agent that safely anesthetizes intact skin. The purpose of this study was to determine if this cream could be safely used for anesthetizing wounds. This investigation evaluated the potential toxicity of EMLA cream in wounds by measuring its effect on host defenses and on the biology of wound repair. In contaminated wounds, EMLA cream elicited an exaggerated inflammatory response that damaged host defenses, inviting the development of infection. As a result of these investigations, we do not recommend the use of EMLA cream in wounds.
EMLA是一种新型外用制剂，可安全地麻醉完整皮肤。本研究的目的是确定这种乳膏是否可安全用于伤口麻醉。本研究通过测量其对宿主防御和伤口修复生物学的影响，评估了EMLA乳膏在伤口中的潜在毒性。在污染伤口中，EMLA乳膏引发了过度的炎症反应，损害了宿主防御，导致感染的发生。基于这些研究结果，我们不建议在伤口中使用EMLA乳膏。
