Hansson C, Holm J, Lillieborg S, Syrén A
Department of Dermatology, University Hospital, Sahlgrenska sjukhuset, Göteborg, Sweden.
Acta Derm Venereol. 1993 Jun;73(3):231-3. doi: 10.2340/000155555573231233.
Repeated topical analgesia with EMLA 5% cream prior to the cleansing of venous leg ulcers was studied. Patients were randomly allocated to a series of 8 treatments with EMLA (n = 22) or to a control group (n = 21). A thick layer of the cream was applied to the ulcers for 30 min. At each of the 8 treatments, local reactions were assessed on a 4-point scale and pain from ulcer cleansing on a visual analogue scale. At the first and the last treatment the area of the ulcer was determined by mapping, a sample for a bacterial culture was taken and the amount of dead tissue, slough and granulation tissue present was assessed. Treatment with EMLA for 30 min significantly decreased the pain from cleansing of the leg ulcers and the frequency of post-cleansing pain. The analgesic effect remained unchanged with successive treatments. Repeated treatment with EMLA in leg ulcers would appear to be safe, as indicated by the absence of any serious untoward events. No statistically significant differences in local reactions or adverse effects on granulation tissue, ulcer area or bacterial flora were observed in the EMLA-treated patients compared with the control patients.
研究了在清洁下肢静脉溃疡之前，使用复方利多卡因乳膏（EMLA）5%霜进行反复局部镇痛的效果。患者被随机分为两组，一组接受8次EMLA治疗（n = 22），另一组作为对照组（n = 21）。在溃疡处涂抹一层厚厚的乳膏，持续30分钟。在8次治疗中的每次治疗时，采用4分制评估局部反应，并使用视觉模拟评分法评估溃疡清洁时的疼痛程度。在第一次和最后一次治疗时，通过绘图确定溃疡面积，采集细菌培养样本，并评估坏死组织、腐肉和肉芽组织的数量。使用EMLA治疗30分钟可显著减轻下肢溃疡清洁时的疼痛以及清洁后疼痛的频率。随着连续治疗，镇痛效果保持不变。在下肢溃疡中反复使用EMLA似乎是安全的，因为未出现任何严重不良事件。与对照组患者相比，接受EMLA治疗的患者在局部反应、对肉芽组织、溃疡面积或细菌菌群的不良反应方面未观察到统计学上的显著差异。
