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移植后卡波西肉瘤

[Kaposi's syndrome following transplantation].

作者信息

Frances C, Farge D, Boisnic S

机构信息

Service de Médecine Interne, Hôpital Pitié-Salpétrière, Paris.

出版信息

J Mal Vasc. 1991;16(2):163-5.

PMID:1861111
Abstract

Kaposi's sarcoma has particularly been described after renal transplantation. More recently, a number of cases have been reported after hepatic or cardiac transplantation. The fostering factors are the same as for the other Kaposi's sarcomas, while the HIV1 or HIV2 serology is always negative. Renal transplantation may increase the natural risk of Kaposi's sarcoma by a factor of 4 to 500. The immunodepressive treatment must be reduced in case of purely cutaneous Kaposi and interrupted in case of visceral involvement. Death generally occurs as a consequence of infections. Kaposi's sarcoma after heart transplantation has a poorer prognosis, with fatal evolution in the four cases observed out of the 967 cardiac transplantations performed in the Ile-de-France region from 1968 to 1990; the cause of death most often is graft rejection or an infection.

摘要

卡波西肉瘤在肾移植后尤为常见。最近,肝移植或心脏移植后也有一些病例报道。其促发因素与其他卡波西肉瘤相同,而HIV1或HIV2血清学检查始终为阴性。肾移植可能使卡波西肉瘤的自然发病风险增加4至500倍。对于单纯皮肤型卡波西肉瘤,必须减少免疫抑制治疗;若累及内脏,则应中断治疗。死亡通常由感染所致。心脏移植后的卡波西肉瘤预后较差,在1968年至1990年于法国岛地区进行的967例心脏移植中,观察到的4例均发展至致命;最常见的死亡原因是移植物排斥或感染。

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