Iakobson G S, Shershnev V N, Gizatulin Z Ia, Shorina G N, Marchenko N I
Biull Eksp Biol Med. 1976 Sep;82(9):1043-5.
Against the background of low steroid metabolism in the liver there was noted some decrease in the rate of corticosterone synthesis by the adrenal gland sections, and also, a decrease in the dehydrogenase activity in the cytoplasm of adrenal cells in male rats 48 hours after partial hepatectomy, as compared to the sham-operated animals. These changes resulted from suppression of the central mechanisms of stress realization due to the lowered steroid metabolism. Intraperitoneal administration of carbon tetrachloride (0.1 ml per 100 g of body weight) at the same periods led to a significant intensification of the steroidogenesis in the adrenal tissue and to the activation of NAD-dependent dehydrogenases in the cytoplasm. The role of toxic injury of the glands in the changes of the functional state of the adrenal cortex cells is discussed.
在肝脏中类固醇代谢较低的背景下，发现部分肝切除术后48小时雄性大鼠肾上腺切片中皮质酮合成速率有所下降，与假手术动物相比，肾上腺细胞胞质中的脱氢酶活性也有所降低。这些变化是由于类固醇代谢降低导致应激反应的中枢机制受到抑制所致。在同一时期腹腔注射四氯化碳（每100克体重0.1毫升）会导致肾上腺组织中类固醇生成显著增强，并使胞质中依赖NAD的脱氢酶激活。文中讨论了腺体毒性损伤在肾上腺皮质细胞功能状态变化中的作用。
