Shorin Iu P, Shershnev V N, Iakobson G S
Biull Eksp Biol Med. 1976 Feb;81(2):173-5.
The activity of cytoplasmic dehydrogenases of the adrenal cells was examined during the prolonged injections of ACTH to Wistar rats. The indices of specific steroid synthesis function of the glands remained relatively high in the course of the whole experiment. Changes in the rats of corticosterone synthesis and dehydrogenase activities were phasic in character; they included an initial synchronic activation the first two days with its subsequent decrease (7 days of ACTH injections). The prevalence of activities of NADP-dependent dehydrogenases in combination with reactivation of steroidogenesis was marked during the concluding phase (13 days) of the experiment. A possibility of the adaptive role of selective activation of NADP-dependent enzymes in the maintenance of a high level of hormone biosynthesis under conditions of prolonged ACTH stimulation is discussed.
在向Wistar大鼠长期注射促肾上腺皮质激素（ACTH）的过程中，对肾上腺细胞的细胞质脱氢酶活性进行了检测。在整个实验过程中，腺体特定类固醇合成功能的指标保持相对较高水平。皮质酮合成和脱氢酶活性在大鼠体内的变化具有阶段性；包括最初两天的同步激活以及随后的下降（注射ACTH 7天）。在实验的最后阶段（13天），NADP依赖性脱氢酶活性的普遍存在与类固醇生成的重新激活是显著的。文中讨论了在长期ACTH刺激条件下，NADP依赖性酶的选择性激活在维持高水平激素生物合成中具有适应性作用的可能性。
