Song Hye Ryoung, Yun Kyung Eun, Park Hye Soon
Department of Family Medicine, Paik Hospital, College of Medicine, Inje University, Seoul, Korea.
Am J Clin Nutr. 2008 Jul;88(1):16-21. doi: 10.1093/ajcn/88.1.16.
Alanine aminotransferase (ALT) is used as a surrogate marker for nonalcoholic fatty liver disease (NAFLD), which is frequently observed among obese subjects. Reported data were scanty about the relation between ALT concentrations and visceral fat accumulation measured by computed tomographic (CT) scanning in a large sample.
We investigated the association between ALT concentrations and visceral fat accumulation measured by CT scanning, among nondiabetic overweight Korean women.
A cross-sectional study was performed in 903 nondiabetic overweight [body mass index (BMI; in kg/m(2)) > or = 25] Korean women aged 20-80 y. The area of abdominal visceral adipose tissue (VAT) was measured by CT scan. Anthropometric and cardiometabolic variables were measured.
Elevated ALT (> 40 IU/L) concentrations were found in 14.9% of the subjects. ALT concentrations were significantly correlated with all anthropometric and cardiometabolic variables after adjustment for age and alcohol consumption (P < 0.05). The adjusted odds ratios for elevated ALT concentrations according to the quartiles of VAT were 1.51 (95% CI: 0.83, 2.76), 3.16 (95% CI: 1.55, 6.49), and 15.15 (95% CI: 4.57, 50.00) in the second (76.9-102.6 cm(2)), the third (102.7-135.0 cm(2)), and the fourth (135.1-382.7 cm(2)) quartiles, respectively, compared with the first quartile (23.0-76.8 cm(2)) (P for trend < 0.001). In the multiple linear regression model, the VAT was significantly positively associated with ALT concentrations (standardized beta = 0.206, P < 0.001), whereas the regression coefficients of other anthropometric and cardiometabolic variables were not significant.
ALT concentrations have a strong association with visceral fat accumulation, and VAT is the main predictor of elevated ALT concentrations in the context of NAFLD among nondiabetic overweight Korean women.
丙氨酸转氨酶（ALT）用作非酒精性脂肪性肝病（NAFLD）的替代标志物，NAFLD在肥胖受试者中很常见。关于在大样本中通过计算机断层扫描（CT）测量的ALT浓度与内脏脂肪堆积之间的关系，报道的数据很少。
我们在非糖尿病超重韩国女性中研究了通过CT扫描测量的ALT浓度与内脏脂肪堆积之间的关联。
对903名年龄在20 - 80岁的非糖尿病超重[体重指数（BMI；单位：kg/m²）≥25]韩国女性进行了一项横断面研究。通过CT扫描测量腹部内脏脂肪组织（VAT）的面积。测量人体测量学和心脏代谢变量。
14.9%的受试者ALT浓度升高（>40 IU/L）。在调整年龄和饮酒量后，ALT浓度与所有人体测量学和心脏代谢变量显著相关（P<0.05）。根据VAT四分位数，ALT浓度升高的校正比值比在第二四分位数（76.9 - 102.6 cm²）为1.51（95%CI：0.83，2.76），第三四分位数（102.7 - 135.0 cm²）为3.16（95%CI：1.55，6.49），第四四分位数（135.1 - 382.7 cm²）为15.15（95%CI：4.57，50.00），与第一四分位数（23.0 - 76.8 cm²）相比（趋势P<0.001）。在多元线性回归模型中，VAT与ALT浓度显著正相关（标准化β = 0.206，P<0.001），而其他人体测量学和心脏代谢变量的回归系数不显著。
ALT浓度与内脏脂肪堆积密切相关，在非糖尿病超重韩国女性的NAFLD背景下，VAT是ALT浓度升高的主要预测因素。
