Yang Xiaolin, Telama Risto, Hirvensalo Mirja, Mattsson Noora, Viikari Jorma S A, Raitakari Olli T
LIKES Research Center for Sport and Health Sciences, Jyväskylä, Finland.
Med Sci Sports Exerc. 2008 Aug;40(8):1424-31. doi: 10.1249/MSS.0b013e318172ced4.
To examine the relationship of physical activity and its changes over a 9-yr follow-up to the prevalence of metabolic syndrome (MetS) in 2060 young adults (24-39 yr) enrolled in the Cardiovascular Risk in Young Finns Study.
Leisure-time physical activity (LTPA) was assessed using a self-report questionnaire completed in connection with a medical examination at two consecutive measurements in 1992 and 2001. By summing the LTPA items, a physical activity index (PAI) was formed for both measurement points according to which the participants were divided into tracking groups: persistently active, increasingly active, decreasingly active, and persistently inactive. MetS in 2001 was defined by the guidelines of the European Group for the Study of Insulin Resistance (EGIR), the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III), and the International Diabetes Federation (IDF). A continuous metabolic risk score was also calculated by summing the z-scores for the metabolic risk factors.
There was a significant linear relationship between MetS and LTPA at baseline in men and at follow-up in both sexes according to all three definitions. Persistent physical activity during 9 yr was associated with a lower prevalence of MetS than persistent physical inactivity on all definitions (all P < 0.05). Similar results were found for increasingly active women (all P < 0.05). All of these associations remained significant after adjustment for potential confounders. In both men and women, the 9-yr change in LTPA was related to the metabolic risk score after adjustments for baseline LTPA, age, smoking, and education.
A physically active lifestyle across the lifespan may prevent or delay the onset of metabolic syndrome in young male and female adults.
在参与芬兰青年人心血管风险研究的2060名年轻成年人（24 - 39岁）中，研究9年随访期间身体活动及其变化与代谢综合征（MetS）患病率之间的关系。
通过一份自填问卷评估闲暇时间身体活动（LTPA），该问卷是在1992年和2001年两次连续体检时填写的。将LTPA项目相加，为两个测量点分别形成一个身体活动指数（PAI），根据该指数将参与者分为追踪组：持续活跃、活动增加、活动减少和持续不活跃。2001年的MetS根据欧洲胰岛素抵抗研究组（EGIR）、美国国家胆固醇教育计划成人治疗专家组第三次报告（NCEP - ATP III）和国际糖尿病联盟（IDF）的指南来定义。还通过将代谢风险因素的z分数相加计算出一个连续的代谢风险评分。
根据所有三种定义，在男性基线时以及在两性随访时，MetS与LTPA之间存在显著的线性关系。在所有定义下，9年期间持续进行身体活动与MetS患病率低于持续不进行身体活动相关（所有P < 0.05）。活动增加的女性也有类似结果（所有P < 0.05）。在对潜在混杂因素进行调整后，所有这些关联仍然显著。在男性和女性中，调整基线LTPA、年龄、吸烟和教育程度后，LTPA的9年变化与代谢风险评分相关。
在整个生命周期中保持积极的生活方式可能预防或延缓年轻男性和女性代谢综合征的发生。
