Sharifi Shahriar, Imani Mohammad, Mirzadeh Hamid, Atai Mohammad, Ziaee Farshid, Bakhshi Raheleh
Novel Drug Delivery Systems Department, Iran Polymer and Petrochemical Institute, P.O. Box 14965/115, Tehran, Iran.
J Biomed Mater Res A. 2009 Sep 1;90(3):830-43. doi: 10.1002/jbm.a.32138.
A series of novel self-crosslinkable and biodegradable polymers, poly(hexamethylene carbonate-fumarate) and poly(hexamethylene carbonate) diacrylate, and their amphiphilic copolymers with polyethylene glycol, poly(ethylene glycol fumarate-co-hexamethylene carbonate-fumarate) (PEGF-co-PHMCF), were developed for tissue engineering using propylene oxide as an acid scavenger. The synthesized polymers are white, which makes them more suitable for self-crosslinking via photopolymerization. These novel polymers were fully characterized using nuclear magnetic resonance spectroscopy, Fourier-transform infrared spectroscopy, gel permeation chromatography, differential scanning calorimetry, and rheometry. The cytocompatibility of the photocrosslinked networks were evaluated by [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay. These polymers can be used as precursors to prepare polymer networks and scaffolds with controlled hydrophilicity, biodegradability, and mechanical characteristics. Results obtained suggest that these polymers are potentially useful as injectable and photocrosslinkable materials for cell delivery, tissue engineering, and drug delivery applications.
一系列新型的可自交联且可生物降解的聚合物，聚（己二酸己二醇酯-富马酸酯）和聚（己二酸己二醇酯）二丙烯酸酯，以及它们与聚乙二醇的两亲性共聚物，聚（富马酸聚乙二醇酯-共-己二酸己二醇酯-富马酸酯）（PEGF-co-PHMCF），以环氧丙烷作为酸清除剂被开发用于组织工程。合成的聚合物为白色，这使得它们更适合通过光聚合进行自交联。使用核磁共振光谱、傅里叶变换红外光谱、凝胶渗透色谱、差示扫描量热法和流变学对这些新型聚合物进行了全面表征。通过[3-(4,5-二甲基噻唑-2-基)-2,5-二苯基溴化四氮唑]试验评估了光交联网络的细胞相容性。这些聚合物可用作前体来制备具有可控亲水性、生物降解性和机械特性的聚合物网络和支架。所得结果表明，这些聚合物作为用于细胞递送、组织工程和药物递送应用的可注射且可光交联的材料具有潜在用途。
