Cieslinski D A, David Humes H
University of Michigan and Veteran's Administration Medical Center, 2215 Fuller Road, Ann Arbor, Michigan 48105.
Biotechnol Bioeng. 1994 Mar 25;43(7):678-81. doi: 10.1002/bit.260430718.
Tissue engineering is a rapidly growing field in biotechnology. The use and packaging of synthetic materials, biologic compounds, and cellular components of specific tissues can be envisioned to replace physiologic function of diseased organs. Long-term ex vivo therapy for kidney failure has been achieved, so that the kidney may be the first solid organ in which tissue engineering concepts can produce an implantable device for long-term in vivo replacement therapy. To replace the kidney's excretory function, an implantable bioartificial kidney requires both a device to replace blood ultrafiltration performed by renal glomeruli and a device to replace transport regulatory function of the renal tubule. The initial concepts for these devices are just beginning to be considered and developed. (c) 1994 John Wiley & Sons, Inc.
组织工程是生物技术领域中一个迅速发展的领域。可以设想使用和包装合成材料、生物化合物以及特定组织的细胞成分来替代患病器官的生理功能。已经实现了针对肾衰竭的长期体外治疗，因此肾脏可能是第一个能够运用组织工程概念制造出用于长期体内替代治疗的可植入装置的实体器官。为了替代肾脏的排泄功能，一个可植入的生物人工肾既需要一个装置来替代由肾小球执行的血液超滤功能，也需要一个装置来替代肾小管的转运调节功能。这些装置的最初概念才刚刚开始被考虑和研发。（c）1994约翰·威利父子公司
