González-Sánchez José L, Zabena Carina, Martínez-Larrad María T, Martínez-Calatrava María J, Pérez-Barba Milagros, Serrano-Ríos Manuel
Department of Internal Medicine II, Hospital Clínico San Carlos, Madrid, Spain.
Clin Endocrinol (Oxf). 2009 Mar;70(3):390-3. doi: 10.1111/j.1365-2265.2008.03335.x. Epub 2008 Jun 27.
Recently independent studies, including genome-wide scans, have shown that variation in the fat mass and obesity associated gene (FTO) were significantly associated with obesity in populations of European origin.
In this study we examined the association between rs9939609 FTO variant and obesity related parameters in a population based-study of 732 unrelated individuals (46.9% males and 53.1% females; ages 35-74 years) from the province of Segovia in Central Spain (Castille).
The AA genotype was significantly more frequent in obese individuals (defined as body mass index >or= 30 kg/m(2), n = 207; 80 males and 127 females) than in non-obese (19.9%vs. 13.7%, P = 0.026). In addition to increased obesity, AA homozygous individuals had higher waist circumference than individuals with AT heterozygous and TT homozygous genotypes. The minor A-allele of rs9939609 was associated with an increased odds ratio (OR) for obesity [OR 1.51, 95% confidence interval (CI) 1.10-2.12] as compared to the TT genotype. This difference was also statistically significant even after the adjustment for sex and age (OR 1.46, 95% CI 1.02-2.07).
Our results support the association of FTO gene variants with obesity, including parameters of visceral (abdominal) obesity, in an adult general population from Spain. Overall we confirm the previously reported association studies between variants in FTO gene and the risk of obesity.
近期包括全基因组扫描在内的独立研究表明，脂肪量和肥胖相关基因（FTO）的变异与欧洲裔人群的肥胖显著相关。
在本研究中，我们对来自西班牙中部塞哥维亚省（卡斯蒂利亚）的732名无亲缘关系的个体（46.9%为男性，53.1%为女性；年龄35 - 74岁）进行了基于人群的研究，检测了rs9939609 FTO变异与肥胖相关参数之间的关联。
AA基因型在肥胖个体（定义为体重指数≥30 kg/m²，n = 207；80名男性和127名女性）中比在非肥胖个体中显著更常见（19.9%对13.7%，P = 0.026）。除了肥胖增加外，AA纯合个体的腰围比AT杂合和TT纯合基因型个体更高。与TT基因型相比，rs9939609的次要A等位基因与肥胖的比值比（OR）增加相关[OR 1.51，95%置信区间（CI）1.10 - 2.12]。即使在对性别和年龄进行调整后，这种差异仍具有统计学意义（OR 1.46，95% CI 1.02 - 2.07）。
我们的结果支持FTO基因变异与肥胖的关联，包括西班牙成年普通人群中内脏（腹部）肥胖的参数。总体而言，我们证实了先前报道的FTO基因变异与肥胖风险之间的关联研究。
