Excellence Centre of Animal and Human Ecology, University of Presov, Slovakia.
Am J Phys Anthropol. 2012 Jan;147(1):30-4. doi: 10.1002/ajpa.21604. Epub 2011 Oct 12.
The rs9939609 SNP located in the first intron of the fat mass and obesity associated gene (FTO) has been found to be associated with common obesity mainly in populations of European descent. The Roma/Gypsy population as an ethnic minority of Asian Indian origin is well known for its adverse health status with a high prevalence of obesity. The main aim of this study was to examine the contribution of the rs9939609 FTO polymorphism to the high prevalence of obesity in the Roma/Gypsy population. Following a number of anthropometric measurements, the FTO rs9939609 polymorphism was genotyped in 312 Roma/Gypsy individuals. We observed significant differences in body mass index (BMI), waist circumference, and waist-to-hip ratio between different genotypes (P = 0.003, P = 0.012, and P = 0.03, respectively). The waist circumference in the subjects with AA genotype was about 7.1 cm larger than in those with TT genotypes (P = 0.005). However, the strongest association of minor allele A of the rs9939609 FTO polymorphism was found with BMI (odds ratio, 1.55; 95% confidence interval, 1.129-2.128; P = 0.007), even after adjusting for age, sex, and smoking status. This study provides the first report of allele and genotype frequencies for the rs9939609 polymorphism and also the first evidence of the association of the FTO variant with obesity in the Roma/Gypsy population.
rs9939609 单核苷酸多态性位于脂肪量和肥胖相关基因 (FTO) 的第一内含子中，主要在欧洲血统人群中与常见肥胖有关。罗姆人/吉普赛人作为亚洲印度血统的少数民族，以其不良健康状况和肥胖高发率而闻名。本研究的主要目的是研究 rs9939609 FTO 多态性对罗姆人/吉普赛人肥胖高发率的贡献。进行了多项人体测量后，对 312 名罗姆人/吉普赛个体的 FTO rs9939609 多态性进行了基因分型。我们观察到不同基因型之间的体重指数 (BMI)、腰围和腰臀比存在显著差异 (P = 0.003、P = 0.012 和 P = 0.03，分别)。AA 基因型受试者的腰围比 TT 基因型受试者大约大 7.1 厘米 (P = 0.005)。然而，rs9939609 FTO 多态性的次要等位基因 A 与 BMI 的相关性最强 (比值比，1.55；95%置信区间，1.129-2.128；P = 0.007)，即使在调整年龄、性别和吸烟状况后也是如此。本研究首次报道了 rs9939609 多态性的等位基因和基因型频率，并且首次证明了 FTO 变体与罗姆人/吉普赛人肥胖之间的关联。
