Murphy E A, Davis J M, Carmichael M D, Gangemi J D, Ghaffar A, Mayer E P
Division of Applied Physiology, Department of Exercise Science, Arnold School of Public Health, University of South Carolina, PHRC #301, 921 Assembly Street, Columbia, SC 29208, USA.
Brain Behav Immun. 2008 Nov;22(8):1152-5. doi: 10.1016/j.bbi.2008.06.004. Epub 2008 Jun 21.
Exercise stress is associated with an increased risk for upper respiratory tract infection (URTI) while moderate exercise has been associated with a decreased risk. We have shown that exercise stress can increase susceptibility (morbidity, symptom severity and mortality) to HSV-1 respiratory infection, but there is little evidence on the effects of stressful exercise on susceptibility to the principal etiological agents of human respiratory infections, including influenza viruses. This study examined the effects of stressful exercise on susceptibility to influenza virus (A/Puerto Rico/8/34 (H1N1)). Mice were assigned to one of two groups: exercise (Ex) or control (Con). Exercise consisted of a treadmill run to volitional fatigue ( approximately 120 min) performed on three consecutive days. Fifteen minutes after the last bout of exercise or rest, mice (n=20-21/group) were intranasally inoculated with a standardized dose of influenza virus (0.25 HAU). Mice were monitored daily for morbidity (time to sickness), symptom severity and mortality (time to death) for 21 days. Exercise stress was associated with an increase in susceptibility to infection (morbidity, mortality and symptom severity on days 6 and 7; P<0.05). These data from a controlled influenza virus challenge model add significantly to the growing body of evidence that severe exercise can increase susceptibility to URTI.
运动应激与上呼吸道感染（URTI）风险增加相关，而适度运动则与风险降低相关。我们已经表明，运动应激会增加对单纯疱疹病毒1型（HSV-1）呼吸道感染的易感性（发病率、症状严重程度和死亡率），但关于应激运动对人类呼吸道感染主要病原体（包括流感病毒）易感性影响的证据很少。本研究考察了应激运动对流感病毒（A/波多黎各/8/34（H1N1））易感性的影响。将小鼠分为两组之一：运动组（Ex）或对照组（Con）。运动包括连续三天在跑步机上跑步至自愿疲劳（约120分钟）。在最后一次运动或休息后15分钟，给小鼠（每组n = 20 - 21只）鼻内接种标准化剂量的流感病毒（0.25血凝素单位）。每天监测小鼠21天的发病率（发病时间）、症状严重程度和死亡率（死亡时间）。运动应激与感染易感性增加相关（第6天和第7天的发病率、死亡率和症状严重程度；P < 0.05）。来自受控流感病毒攻击模型的这些数据显著补充了越来越多的证据，即剧烈运动可增加对URTI的易感性。
