Dimitroula Hariklia V, Hatzitolios Apostolos I, Karvounis Haralambos I
First Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Greece.
Neurologist. 2008 Jul;14(4):238-42. doi: 10.1097/NRL.0b013e31815c666b.
Although in the past decade a large number of studies have been performed to identify the relationship between uric acid and stroke, the issue remains unresolved and it is not clear whether the correlation between uric acid and stroke is circumstantial or causal.
Some studies have found uric acid predictive for the development of cardiovascular disease, whereas others have failed to identify uric acid as a significant and independent risk factor after controlling for other atherosclerotic risk factors. Furthermore, uric acid, a powerful endogenous antioxidant, is increased in oxidative stress situations such as stroke. Still, it remains controversial whether elevated serum uric acid is neuroprotective or injurious at the onset of acute stroke.
Large trials are required to provide definite answers in clinical practice and to reevaluate the goals of hypouricemic treatment in subjects with increased cardiovascular risk or during an acute cardiovascular event like stroke. This review tries to keep pace with the data concerning the association between uric acid and stroke.
尽管在过去十年中已经进行了大量研究以确定尿酸与中风之间的关系，但该问题仍未解决，尿酸与中风之间的相关性是偶然的还是因果关系尚不清楚。
一些研究发现尿酸可预测心血管疾病的发生，而另一些研究在控制其他动脉粥样硬化危险因素后未能将尿酸确定为显著且独立的危险因素。此外，尿酸是一种强大的内源性抗氧化剂，在中风等氧化应激情况下会升高。然而，血清尿酸升高在急性中风发作时是具有神经保护作用还是有害作用仍存在争议。
需要进行大型试验以在临床实践中提供明确答案，并重新评估心血管风险增加的受试者或中风等急性心血管事件期间降尿酸治疗的目标。本综述试图跟上有关尿酸与中风关联的数据。
