Kim Hee Young, Wang Jigong, Chung Kyungsoon, Chung Jin Mo
Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-1069, USA.
Neurosci Lett. 2008 Sep 12;442(2):161-4. doi: 10.1016/j.neulet.2008.06.074. Epub 2008 Jul 3.
Ankle sprain is a frequent injury in humans that results in pain, swelling and difficulty in walking on the affected side. Currently a suitable animal model resembling human ankle sprain is lacking. Here, we describe an animal ankle sprain model induced by ankle ligament injury (ALI) in rats. Cutting combinations of the lateral ankle ligament complex produced pain, edema and difficulty of weight bearing, thereby mimicking severe (grade III) ankle sprain in humans. Analgesic compounds, morphine and indomethacin, significantly reversed the reduced weight bearing, thus indicating that reduction of weight bearing is partially due to pain. The ALI model is a new ankle sprain model that may be useful for the study of ankle sprain pain mechanisms and treatments, as well as for the screening of new analgesic drugs.
踝关节扭伤是人类常见的损伤，会导致疼痛、肿胀以及患侧行走困难。目前尚缺乏一种类似于人类踝关节扭伤的合适动物模型。在此，我们描述一种通过大鼠踝关节韧带损伤（ALI）诱导的动物踝关节扭伤模型。切断外侧踝关节韧带复合体的不同组合会产生疼痛、水肿和负重困难，从而模拟人类严重（III级）踝关节扭伤。镇痛化合物吗啡和吲哚美辛能显著逆转负重减轻的情况，这表明负重减轻部分是由疼痛所致。ALI模型是一种新的踝关节扭伤模型，可能有助于踝关节扭伤疼痛机制和治疗的研究，以及新型镇痛药的筛选。
