Wang Fei, Kalmar Jessica H, Edmiston Elliot Kale, Chepenik Lara G, Bhagwagar Zubin, Spencer Linda, Pittman Brian, Jackowski Marcel, Papademetris Xenophon, Constable R Todd, Blumberg Hilary P
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Department of Psychiatry, VA CT Healthcare System, West Haven, Connecticut.
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut; Department of Psychiatry, VA CT Healthcare System, West Haven, Connecticut.
Biol Psychiatry. 2008 Oct 15;64(8):730-733. doi: 10.1016/j.biopsych.2008.06.001. Epub 2008 Jul 11.
Abnormalities in the anterior interhemispheric connections provided by the corpus callosum (CC) have long been implicated in bipolar disorder (BD). In this study, we used complementary diffusion tensor imaging methods to study the structural integrity of the CC and localization of potential abnormalities in BD.
Subjects included 33 participants with BD and 40 healthy comparison participants. Fractional anisotropy (FA) measures were compared between groups with region of interest (ROI) methods to investigate the anterior, middle, and posterior CC and voxel-based methods to further localize abnormalities.
In ROI-based analyses, FA was significantly decreased in the anterior and middle CC in the BD group (p < .05). Voxel-based analyses similarly localized group differences to the genu, rostral body, and anterior midbody of CC (p < .05, corrected).
The findings demonstrate abnormalities in the structural integrity of the anterior CC in BD that might contribute to altered interhemispheric connectivity in this disorder.
长期以来，胼胝体（CC）提供的半球间前连接异常一直被认为与双相情感障碍（BD）有关。在本研究中，我们使用互补扩散张量成像方法来研究BD患者CC的结构完整性和潜在异常的定位。
研究对象包括33名BD患者和40名健康对照者。采用感兴趣区域（ROI）方法比较两组间的分数各向异性（FA）测量值，以研究CC的前部、中部和后部，并采用基于体素的方法进一步定位异常。
在基于ROI的分析中，BD组CC前部和中部的FA显著降低（p < .05）。基于体素的分析同样将组间差异定位到CC膝部、嘴侧体部和前中部（p < .05，校正）。
研究结果表明BD患者CC前部的结构完整性存在异常，这可能导致该疾病中半球间连接改变。
