Earle-Boyer E A, Serper M R, Davidson M, Harvey P D
Mt. Sinai School of Medicine, New York, NY 10029-6574.
Psychiatry Res. 1991 Apr;37(1):47-56. doi: 10.1016/0165-1781(91)90105-x.
Medicated (n = 17) and unmedicated (n = 17) schizophrenic patients were compared to a normal control group (n = 19) on their performance on auditory and visual versions of the Continuous Performance Test (CPT). Within each stimulus modality, performance was examined on lexical and nonlexical target stimuli. Neuromotor competence was assessed on the basis of motor speed and proficiency. Normal subjects made fewer errors of all types than schizophrenic patients. Unmedicated patients made significantly more errors on nonlexical stimuli than medicated patients, with medication status found not to be associated with stimulus modality effects. Motor proficiency was associated with CPT performance in the medicated patients, but not the unmedicated ones, although this difference in correlations did not account for the group differences between these patients. The authors discuss the implications of these data for the type of cognitive and attentional functions that are affected by medication in schizophrenia.
对17名服用药物的精神分裂症患者、17名未服用药物的精神分裂症患者以及19名正常对照组进行了连续性能测试（CPT）听觉和视觉版本的表现比较。在每种刺激模式下，对词汇和非词汇目标刺激的表现进行了检查。根据运动速度和熟练程度评估神经运动能力。正常受试者比精神分裂症患者出现的各类错误更少。未服用药物的患者在非词汇刺激上出现的错误明显多于服用药物的患者，且发现用药状态与刺激模式效应无关。运动熟练程度与服用药物患者的CPT表现相关，但与未服用药物的患者无关，尽管这种相关性差异并不能解释这些患者之间的组间差异。作者讨论了这些数据对精神分裂症中受药物影响的认知和注意力功能类型的影响。
