Harvey P D, Pedley M
Department of Psychiatry, Mt. Sinai School of Medicine, New York, NY 10029.
Schizophr Res. 1989 May-Jun;2(3):295-300. doi: 10.1016/0920-9964(89)90006-6.
Medicated and unmedicated schizophrenics were compared (both n = 18) on visual and auditory digit serial recall tasks with interspersed distraction. It was found that both medicated and unmedicated schizophrenics were distractible auditorally, but that only unmedicated schizophrenics were distractible on visually presented information. Positive, but not negative thought disorder predicted poorer auditory, but not visual, distraction performance for the medicated patients. For the unmedicated patients, positive thought disorder was also associated with auditory, but not visual distraction performance. Negative thought disorder was also a predictor of distraction performance, both visual and auditory, for the unmedicated patients. These results are interpreted in terms of their implications for the effects of medication on absolute performance levels in laboratory tasks and on associations between laboratory and clinical indices.
对接受药物治疗和未接受药物治疗的精神分裂症患者（每组n = 18）进行了视觉和听觉数字序列回忆任务测试，并穿插了干扰项。结果发现，接受药物治疗和未接受药物治疗的精神分裂症患者在听觉上都容易受到干扰，但只有未接受药物治疗的精神分裂症患者在视觉呈现信息时容易受到干扰。对于接受药物治疗的患者，阳性思维障碍（而非阴性思维障碍）预示着较差的听觉干扰表现，但视觉干扰表现不受影响。对于未接受药物治疗的患者，阳性思维障碍也与听觉干扰表现相关，但与视觉干扰表现无关。阴性思维障碍也是未接受药物治疗患者视觉和听觉干扰表现的一个预测因素。这些结果根据其对药物治疗对实验室任务中绝对表现水平以及实验室与临床指标之间关联的影响进行了解释。
