Riccioni Graziano, D'Orazio Nicolantonio, Palumbo Nicola, Bucciarelli Valentina, Ilio Emanuela di, Bazzano Lydia A, Bucciarelli Tonino
Cardiology Unit, San Camillo de Lellis Hospital, Manfredonia, Foggia, Italy.
Eur J Cardiovasc Prev Rehabil. 2009 Jun;16(3):351-7. doi: 10.1097/HJR.0b013e328325d807.
Few studies have examined the relationship among carotid atherosclerosis, vascular risk factors, and antioxidant plasma concentrations, and those that have reported conflicting results. The aim of this study was to assess the relationship between asymptomatic carotid atherosclerosis, as defined by carotid intima-media thickness (CIMT), and inflammatory markers, plasma lipids and serum antioxidant vitamins.
We examined baseline characteristics of the 640 participants in the Asymptomatic Carotid Atherosclerotic Disease In Manfredonia Study. All participants were asymptomatic with respect to carotid artery disease in 2006-2007 and underwent physical examination with carotid ultrasound investigation, the collection of medical history and laboratory data. Analysis of variance methods were used to examine differences between participants by category of CIMT. Of the 640 participants, 291 did not have evidence of carotid atherosclerosis (CIMT<0.8 mm), 232 were found to have some atherosclerosis (0.8 mm< or =CIMT<1.2 mm), and 117 were found to have extensive atherosclerosis (CIMT>1.2 mm). Among participants with CIMT> or =0.8 mm, body mass index, blood pressures, total cholesterol, LDL cholesterol, triglycerides, uric acid, C-reactive protein, and fibrinogen were significantly higher, whereas concentrations of vitamin A, vitamin E, lycopene, and beta-carotene were all significantly lower when compared with participants who did not show evidence of carotid atherosclerosis (P<0.001).
The optimal control of hypertension, diabetes, and dyslipidemia, in addition to smoking cessation and an adequate intake of antioxidant micronutrients from foods represent a key for the prevention of atherosclerotic disease.
很少有研究探讨颈动脉粥样硬化、血管危险因素和血浆抗氧化剂浓度之间的关系，且已有的研究报告结果相互矛盾。本研究的目的是评估由颈动脉内膜中层厚度（CIMT）定义的无症状颈动脉粥样硬化与炎症标志物、血浆脂质和血清抗氧化维生素之间的关系。
我们研究了曼弗雷多尼亚无症状颈动脉粥样硬化疾病研究中640名参与者的基线特征。所有参与者在2006 - 2007年时均无颈动脉疾病症状，并接受了颈动脉超声检查、病史采集和实验室数据收集的体格检查。采用方差分析方法按CIMT类别检查参与者之间的差异。在640名参与者中，291人没有颈动脉粥样硬化证据（CIMT < 0.8 mm），232人被发现有一些粥样硬化（0.8 mm≤CIMT < 1.2 mm），117人被发现有广泛的粥样硬化（CIMT > 1.2 mm）。与没有颈动脉粥样硬化证据的参与者相比，在CIMT≥0.8 mm的参与者中，体重指数、血压、总胆固醇、低密度脂蛋白胆固醇、甘油三酯、尿酸、C反应蛋白和纤维蛋白原显著更高，而维生素A、维生素E、番茄红素和β - 胡萝卜素的浓度均显著更低（P < 0.001）。
除了戒烟和从食物中充分摄入抗氧化微量营养素外，对高血压、糖尿病和血脂异常进行最佳控制是预防动脉粥样硬化疾病的关键。
