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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Glowa J R, Bacher J D, Herkenham M, Gold P W

Clinical Neuroendocrinology Branch, NIMH, NIH, Bethesda, MD.

Prog Neuropsychopharmacol Biol Psychiatry. 1991;15(3):379-91. doi: 10.1016/0278-5846(91)90069-d.

Rhesus monkeys were equipped with a novel intracerebroventricular (i.c.v.) cannula system and trained to respond under operant schedules of food presentation or termination of stimuli associated with the delivery of shock (escape). 2. CRH decreased food-maintained behavior in a dose-related manner over the range of (0.3-10 micrograms/kg) but did not affect escape responding, demonstrating a selective effect on food-maintained responding. 3. This selective effect was related to the tendency for responding to stop after delivery of a food pellet when higher doses of CRH were given, consistent with the notion that a conditioned aversion to food was established in the presence of CRH. 4. This may suggest that in hyperaroused clinical states such as depression and anorexia nervosa, focus is shifted away from appetitive tasks as a result of increased levels of CRH.

恒河猴被植入了一种新型的脑室内（i.c.v.）插管系统，并接受训练，使其在食物呈现的操作性程序或与电击释放相关的刺激终止（逃避）条件下做出反应。2. 在（0.3 - 10微克/千克）的剂量范围内，促肾上腺皮质激素释放激素（CRH）以剂量相关的方式降低了食物维持行为，但不影响逃避反应，表明对食物维持反应有选择性作用。3. 这种选择性作用与给予较高剂量CRH时食物颗粒递送后反应停止的倾向有关，这与在CRH存在下建立对食物的条件性厌恶的观点一致。4. 这可能表明，在诸如抑郁症和神经性厌食症等过度唤醒的临床状态下，由于CRH水平升高，注意力从食欲任务上转移开。

Glowa J R, Bacher J D, Herkenham M, Gold P W

Clinical Neuroendocrinology Branch, NIMH, NIH, Bethesda, MD.

Prog Neuropsychopharmacol Biol Psychiatry. 1991;15(3):379-91. doi: 10.1016/0278-5846(91)90069-d.

Rhesus monkeys were equipped with a novel intracerebroventricular (i.c.v.) cannula system and trained to respond under operant schedules of food presentation or termination of stimuli associated with the delivery of shock (escape). 2. CRH decreased food-maintained behavior in a dose-related manner over the range of (0.3-10 micrograms/kg) but did not affect escape responding, demonstrating a selective effect on food-maintained responding. 3. This selective effect was related to the tendency for responding to stop after delivery of a food pellet when higher doses of CRH were given, consistent with the notion that a conditioned aversion to food was established in the presence of CRH. 4. This may suggest that in hyperaroused clinical states such as depression and anorexia nervosa, focus is shifted away from appetitive tasks as a result of increased levels of CRH.

恒河猴被植入了一种新型的脑室内（i.c.v.）插管系统，并接受训练，使其在食物呈现的操作性程序或与电击释放相关的刺激终止（逃避）条件下做出反应。2. 在（0.3 - 10微克/千克）的剂量范围内，促肾上腺皮质激素释放激素（CRH）以剂量相关的方式降低了食物维持行为，但不影响逃避反应，表明对食物维持反应有选择性作用。3. 这种选择性作用与给予较高剂量CRH时食物颗粒递送后反应停止的倾向有关，这与在CRH存在下建立对食物的条件性厌恶的观点一致。4. 这可能表明，在诸如抑郁症和神经性厌食症等过度唤醒的临床状态下，由于CRH水平升高，注意力从食欲任务上转移开。