Wearden John H, Smith-Spark James H, Cousins Rosanna, Edelstyn Nicola M J, Cody Frederick W J, O'Boyle Donald J
School of Psychology, Keele University, Keele, Staffordshire, UK.
Q J Exp Psychol (Hove). 2009 Jan;62(1):33-40. doi: 10.1080/17470210802229047. Epub 2008 Feb 20.
Patients with a diagnosis of Parkinson's disease and age- and IQ-matched controls estimated the duration of short 500-Hz tones (325-1,225 ms), on trials where the tone was either preceded by 3 s of 5-Hz clicks, or presented without clicks. The click manipulation had been shown in earlier studies with student participants to make verbal estimates longer. Patients were tested both on and off their dopaminergic medication, and controls were also tested in two sessions. Verbal estimates were markedly and significantly longer on trials with clicks than on those without clicks for both the patients and the controls, but there were no significant performance differences between patients or controls, nor between the on and off medication sessions in the patients. The study shows that a manipulation of subjective time, which has had small but consistent effects in student participants, also affects timing in patients and adds to a growing body of evidence that timing in patients with Parkinson's disease may in many cases have the same characteristics as those of neurologically intact control groups.
被诊断患有帕金森病的患者以及年龄和智商匹配的对照组，在短500赫兹纯音（325 - 1225毫秒）持续时间估计试验中，该纯音要么在之前有3秒的5赫兹滴答声，要么无滴答声呈现。在早期针对学生参与者的研究中已表明，滴答声操作会使言语估计时间变长。患者在服用和未服用多巴胺能药物时均接受测试，对照组也分两个阶段进行测试。对于患者和对照组而言，有滴答声的试验中的言语估计明显且显著长于无滴答声的试验，但患者之间、对照组之间以及患者服用和未服用药物阶段之间均无显著的表现差异。该研究表明，一种对主观时间的操作，在学生参与者中产生了虽小但一致的影响，同样会影响患者的时间感知，并且越来越多的证据表明，帕金森病患者的时间感知在许多情况下可能与神经功能正常的对照组具有相同特征。
