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操作变量对10.5立方米喷射环流生物反应器中液体循环的影响。

Influence of operating variables on liquid circulation in a 10.5-m(3) jet loop bioreactor.

作者信息

García-Salas S, Flores-Cotera L B

机构信息

Department of Biotechnology and Bioengineering, Centro de Investigación y de Estudios Avanzados del IPN, Apdo. Postal 14-740, Méxica 07300 D.F., México.

出版信息

Biotechnol Bioeng. 1995 Jun 5;46(5):408-14. doi: 10.1002/bit.260460503.

DOI:10.1002/bit.260460503
PMID:18623331
Abstract

A 10.5-m(3) concentric tube jet loop reactor was used to study the influence of the working liquid volume, mean superficial air velocity, operating pressure, downcomer aeration, liquid jet velocity, and two ratios of draft tube/reactor diameter (D(t)/D) on liquid circulation time (T(c)). The experiments were carried out in a water-air system with the use of the acid pulse method. Results showed that circulation time was independent of the working liquid volume over a certain minimum liquid level, whereas downcomer aeration and D(t)/D ratio appeared as amenable parameters to achieve a high degree of control over liquid circulation and mixing efficiency, and to optimize the overall reactor performance. Increasing the operating pressure caused a reduction of the liquid circulation rate. However, ionger residence times of the air bubbles and the higher mass transfer driving force that result at higher pressures improve oxygen utilization. The relationship between T(c) and air load was independent of the operating pressure, provided the correlation is given as a function of the mean superficial air velocity. Neither liquid circulation nor gas holdup were significantly affected by liquid jet velocity. (c) 1995 John Wiley & Sons, Inc.

摘要

采用一个10.5立方米的同心管喷射环流反应器,研究工作液体体积、平均表观气速、操作压力、降液管曝气、液体喷射速度以及两个导流筒/反应器直径比(D(t)/D)对液体循环时间(T(c))的影响。实验在水-空气系统中采用酸脉冲法进行。结果表明,在一定的最低液位以上,循环时间与工作液体体积无关,而降液管曝气和D(t)/D比是实现对液体循环和混合效率高度控制以及优化整个反应器性能的合适参数。提高操作压力会导致液体循环速率降低。然而,在较高压力下产生的气泡停留时间延长和传质驱动力增加,提高了氧气利用率。如果将T(c)与空气负荷之间的关系表示为平均表观气速的函数,则该关系与操作压力无关。液体喷射速度对液体循环和气体滞留率均无显著影响。(c)1995约翰威立父子公司。

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