Kirkham Tim
School of Psychology, University of Liverpool, UK.
J Neuroendocrinol. 2008 Sep;20(9):1099-100. doi: 10.1111/j.1365-2826.2008.01762.x. Epub 2008 Jul 8.
Cannabis exerts its actions by mimicking 'endocannabinoid' neuromodulators at CB1 receptors in brain and peripheral tissues. The endocannabinoids both stimulate appetite by increasing food craving and enjoyment and promote the deposition of energy as fat in adipose tissues. These findings have raised the possibility of CB1 antagonists as a novel class of anti-obesity agents.
大麻通过在大脑和外周组织的CB1受体上模拟“内源性大麻素”神经调节剂来发挥作用。内源性大麻素既能通过增加食欲和愉悦感来刺激食欲，又能促进能量以脂肪的形式在脂肪组织中沉积。这些发现增加了CB1拮抗剂作为一类新型抗肥胖药物的可能性。
