Abdwani R, Rizvi S G, El-Nour I
Department of Child Health, Sultan Qaboos University Hospital, Muscat, Oman.
Lupus. 2008 Jul;17(7):683-6. doi: 10.1177/0961203307087611.
There is a worldwide variation in the incidence of childhood manifestation of systemic lupus erythematosus, which may be related to environmental, genetic and geographical factors. The aim of the study is to describe for the first time the clinical and immunological characteristics of childhood onset systemic lupus erythematosus at diagnosis in the Sultanate of Oman. We retrospectively reviewed the records of 50 children with systemic lupus erythematosus fulfilling the American College of Rheumatology criteria between 1990 and 2006. There were 42 girls and eight boys. The mean age of disease onset was low at 8.6 years (SD 3.1). The female:male ratio was 5.3:1. The most frequent clinical manifestations at initial diagnosis were: articular (76%), cutaneous (70%), haematological (68%) and renal (64%) dominated by class IV nephritis, pulmonary (26%), neuropsychiatric (18%) and cardiac (10%). A positive antinuclear antibody (>1:80) was present in 94% at diagnosis. Positive anti-double stranded DNA was present in 82% and low complement levels were present in 84% at diagnosis. This is the first review of childhood onset systemic lupus erythematosus in the Sultanate of Oman.
系统性红斑狼疮儿童期表现的发病率在全球范围内存在差异，这可能与环境、遗传和地理因素有关。本研究的目的是首次描述阿曼苏丹国儿童期起病的系统性红斑狼疮在诊断时的临床和免疫学特征。我们回顾性分析了1990年至2006年间符合美国风湿病学会标准的50例系统性红斑狼疮患儿的记录。其中有42名女孩和8名男孩。疾病开始时的平均年龄较低，为8.6岁（标准差3.1）。男女比例为5.3:1。初次诊断时最常见的临床表现为：关节症状（76%）、皮肤症状（70%）、血液系统症状（68%）和肾脏症状（64%），以IV级肾炎为主，肺部症状（26%）、神经精神症状（18%）和心脏症状（10%）。诊断时94%的患儿抗核抗体阳性（>1:80）。诊断时82%的患儿抗双链DNA阳性，84%的患儿补体水平低。这是对阿曼苏丹国儿童期起病的系统性红斑狼疮的首次综述。
