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失眠是慢波睡眠的一种疾病吗?

Is insomnia a disease of slow-wave sleep?

作者信息

Gaillard J M

出版信息

Eur Neurol. 1976;14(6):473-84. doi: 10.1159/000114775.

DOI:10.1159/000114775
PMID:186267
Abstract

The aim of this paper is to examine if a disturbance of slow-wave sleep may partly account for the imbalance between waking and sleep observed in insomnia. 40 normal subjects and 40 insomniacs were recorded in the laboratory. No direct interregulation appeared between total sleep and REM sleep on one hand, and between slow-wave sleep and REM sleep on the other. Slow-wave sleep, however, was linked to the waking-sleep imbalance, as low values of stages 3 and 4 were statistically associated with low total sleep duration. The reduction of slow-wave sleep could not merely be attributed to an increased pressure of wakefulness. Our results indicate that it represents probably a disturbance in itself, perhaps related in some cases to a precocious senescence of sleep, but do not account alone for all sleep disturbances.

摘要

本文旨在研究慢波睡眠障碍是否可能部分解释失眠中观察到的清醒与睡眠之间的失衡。在实验室对40名正常受试者和40名失眠患者进行了记录。一方面,总睡眠与快速眼动睡眠之间,另一方面,慢波睡眠与快速眼动睡眠之间均未出现直接的相互调节。然而,慢波睡眠与清醒-睡眠失衡有关,因为3期和4期睡眠值较低与总睡眠时间较短在统计学上相关。慢波睡眠的减少不能仅仅归因于清醒压力的增加。我们的结果表明,它本身可能代表一种障碍,在某些情况下可能与睡眠的过早衰老有关,但并不能单独解释所有的睡眠障碍。

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Is insomnia a disease of slow-wave sleep?失眠是慢波睡眠的一种疾病吗?
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Clin Neurophysiol. 2021 Feb;132(2):545-553. doi: 10.1016/j.clinph.2020.12.004. Epub 2020 Dec 19.
2
Cerebral asymmetry in insomnia sufferers.失眠患者的大脑不对称性。
Front Neurol. 2012 Mar 30;3:47. doi: 10.3389/fneur.2012.00047. eCollection 2012.
3
Sleep in normal and pathological aging.
Experientia. 1983 Jun 15;39(6):551-8. doi: 10.1007/BF01971096.
4
Human slow wave sleep: a review and appraisal of recent findings, with implications for sleep functions, and psychiatric illness.人类慢波睡眠:近期研究结果的综述与评估,及其对睡眠功能和精神疾病的影响
Experientia. 1992 Oct 15;48(10):941-54. doi: 10.1007/BF01919141.