Fidan Isil, Kalkanci Ayse, Yesilyurt Emine, Yalcin Burce, Erdal Berna, Kustimur Semra, Imir Turgut
Department of Medical Microbiology, Faculty of Medicine, Gazi University, Ankara, Turkey.
Mycoses. 2009 Jan;52(1):29-34. doi: 10.1111/j.1439-0507.2008.01545.x. Epub 2008 Jun 21.
Saccharomyces boulardii (S. boulardii) is a probiotic and used in the prevention or treatment of diarrhoea. Saccharomyces boulardii has many mechanisms to protect the host against diarrhoeal pathogens. It might modulate the immune system. In this study, the influence of S. boulardii on the secretion of cytokines from intraepithelial lymphocytes (IELs) infected with Escherichia coli (E. coli) and Candida albicans (C. albicans) was investigated in vitro. Cytokine levels were determined by enzyme-linked immunosorbent assay. The secretion of proinflammatory cytokines such as interleukin (IL)-1beta was decreased in the infected IELs incubated with S. boulardii, but different from it, anti-inflammatory cytokine levels such as IL-4 and IL-10, however, were found to be higher. These findings demonstrated that S. boulardii may have protective effects against diarrhoeal pathogens by reducing the proinflammatory response.
布拉酵母菌是一种益生菌，用于预防或治疗腹泻。布拉酵母菌有多种机制来保护宿主抵御腹泻病原体。它可能会调节免疫系统。在本研究中，体外研究了布拉酵母菌对感染大肠杆菌和白色念珠菌的上皮内淋巴细胞（IEL）细胞因子分泌的影响。通过酶联免疫吸附测定法测定细胞因子水平。在用布拉酵母菌孵育的感染IEL中，促炎细胞因子如白细胞介素（IL）-1β的分泌减少，但与之不同的是，抗炎细胞因子如IL-4和IL-10的水平则较高。这些发现表明，布拉酵母菌可能通过减少促炎反应对腹泻病原体具有保护作用。
