Abid Rameesha, Waseem Hassan, Ali Jafar, Ghazanfar Shakira, Muhammad Ali Ghulam, Elasbali Abdelbaset Mohamed, Alharethi Salem Hussain
Department of Biotechnology, University of Sialkot, Sialkot 51310, Pakistan.
National Agriculture Research Center, National Institute of Genomics and Agriculture Biotechnology (NIGAB), Islamabad 44100, Pakistan.
J Fungi (Basel). 2022 Apr 24;8(5):444. doi: 10.3390/jof8050444.
var. is best known for its treatment efficacy against different gastrointestinal diseases. This probiotic yeast can significantly protect the normal microbiota of the human gut and inhibit the pathogenicity of different diarrheal infections. Several clinical investigations have declared var. a biotherapeutic agent due to its antibacterial, antiviral, anti-carcinogenic, antioxidant, anti-inflammatory and immune-modulatory properties. Oral or intramuscular administration of var. can remarkably induce health-promoting effects in the host body. Different intrinsic and extrinsic factors are responsible for its efficacy against acute and chronic gut-associated diseases. This review will discuss the clinical and beneficial effects of var. in the treatment and prevention of different metabolic diseases and highlight some of its health-promising properties. This review article will provide fundamental insights for new avenues in the fields of biotherapeutics, antimicrobial resistance and one health.
var. 因其对不同胃肠道疾病的治疗效果而最为人所知。这种益生菌酵母可以显著保护人类肠道的正常微生物群，并抑制不同腹泻感染的致病性。几项临床研究已宣布var. 为一种生物治疗剂，因其具有抗菌、抗病毒、抗癌、抗氧化、抗炎和免疫调节特性。口服或肌肉注射var. 可在宿主体内显著诱导促进健康的效果。不同的内在和外在因素决定了其对急慢性肠道相关疾病的疗效。本综述将讨论var. 在治疗和预防不同代谢疾病方面的临床和有益效果，并突出其一些有前景的健康特性。这篇综述文章将为生物治疗、抗菌耐药性和同一健康领域的新途径提供基本见解。
