与t(16;21)(p11;q22)/-融合基因相关的急性嗜碱性粒细胞白血病。
Acute basophilic leukemia associated with the t(16;21)(p11;q22)/- fusion gene.
作者信息
Toda Yusuke, Nagai Yuya, Shimomura Daiki, Kishimori Chiyuki, Tsuda Katsuyo, Fukutsuka Katsuhiro, Hayashida Masahiko, Ohno Hitoshi
机构信息
Department of Hematology Tenri Hospital Tenri Nara Japan.
Department of Laboratory Medicine Tenri Hospital Tenri Nara Japan.
出版信息
Clin Case Rep. 2017 Oct 11;5(12):1938-1944. doi: 10.1002/ccr3.1219. eCollection 2017 Dec.
We herein report a rare case of acute basophilic leukemia with t(16;21)(p11;q22) generating the - fusion gene. The basophilic nature of leukemia blasts was demonstrated by cytomorphology, toluidine blue metachromasia, mature basophil-associated antigen expression, and characteristic granules under electron microscopy. The molecular link between t(16;21)/- and basophilic differentiation remains unclear.
我们在此报告一例罕见的急性嗜碱性粒细胞白血病，伴有产生 - 融合基因的t(16;21)(p11;q22)。白血病原始细胞的嗜碱性通过细胞形态学、甲苯胺蓝异染性、成熟嗜碱性粒细胞相关抗原表达以及电子显微镜下的特征性颗粒得以证实。t(16;21)/- 与嗜碱性分化之间的分子联系仍不清楚。
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