Dingli David, Traulsen Arne, Pacheco Jorge M
Division of Hematology, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Proc Biol Sci. 2008 Oct 22;275(1649):2389-92. doi: 10.1098/rspb.2008.0506.
Haemopoiesis is a fundamental physiologic process found in many animals. Among mammals, the diversity in size and function required suitable adaptations of this process. In this work, we use allometric principles to determine whether this required a change in the basic architecture of haemopoiesis. We show that it is possible to express both the number and rate with which haemopoietic stem cells replicate as well as total marrow output across all mammals as a function of adult mass. This unified view, which is compatible with the existing data, suggests that there was no need for major adaptations in the architecture of haemopoiesis across mammals.
造血作用是许多动物体内存在的一种基本生理过程。在哺乳动物中，由于体型大小和功能的多样性，这一过程需要进行适当的适应性调整。在这项研究中，我们运用异速生长原理来确定这是否需要改变造血作用的基本架构。我们发现，将所有哺乳动物的造血干细胞复制数量和速率以及骨髓总输出量表示为成年体重的函数是可行的。这一与现有数据相符的统一观点表明，哺乳动物的造血架构无需进行重大调整。
