人类造血干细胞库的个体发生性生长。
Ontogenic growth of the haemopoietic stem cell pool in humans.
作者信息
Dingli David, Pacheco Jorge M
机构信息
Division of Hematology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
出版信息
Proc Biol Sci. 2007 Oct 7;274(1624):2497-2501. doi: 10.1098/rspb.2007.0780.
Recently, the size of the active stem cell pool has been predicted to scale allometrically with the adult mass of mammalian species with a 3/4 power exponent, similar to what has been found to occur for the resting metabolic rate across species. Here we investigate the allometric scaling of human haemopoietic stem cells (HSCs) during ontogenic growth and predict a linear scaling with body mass. We also investigate the allometric scaling of resting metabolic rate during growth in humans and find a linear scaling with mass similar to that of the haemopoietic stem cell pool. Our findings suggest a common underlying organizational principle determining the linear scaling of both the stem cell pool and resting metabolic rate with mass during ontogenic growth within the human species, combined with a 3/4 scaling with adult mass across mammalian species. It is possible that such common principles remain valid for haemopoiesis in other mammalian species.
最近，据预测，活跃干细胞库的大小与哺乳动物物种的成年体重呈异速生长关系，其幂指数为3/4，这与跨物种静息代谢率的情况类似。在此，我们研究了人类造血干细胞（HSCs）在个体发育生长过程中的异速生长缩放，并预测其与体重呈线性缩放关系。我们还研究了人类生长过程中静息代谢率的异速生长缩放，发现其与体重呈线性缩放关系，类似于造血干细胞库。我们的研究结果表明，存在一个共同的潜在组织原则，它决定了人类个体发育生长过程中干细胞库和静息代谢率与体重的线性缩放关系，同时也决定了跨哺乳动物物种与成年体重的3/4缩放关系。这种共同原则在其他哺乳动物物种的造血过程中可能同样适用。
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