高级别胶质瘤患者的健康相关生活质量
Health-related quality of life in patients with high-grade glioma.
作者信息
Cheng Jin-xiang, Zhang Xiang, Liu Bo-Lin
机构信息
Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province 710032, PR China.
出版信息
Neuro Oncol. 2009 Feb;11(1):41-50. doi: 10.1215/15228517-2008-050. Epub 2008 Jul 15.
Abstract
Health-related quality of life (HRQOL) has become an increasingly important endpoint in cancer studies; however, the research into the HRQOL of patients with high-grade glioma (HGG) is sparse compared with that for patients with other neoplasms. Owing to the specific location and poor prognosis, it is more important and difficult to study HRQOL in patients with HGG than in those with other tumors; furthermore, the study of HRQOL in patients with HGG differs from that for patients with other tumors. In this review, we identified and compared the most frequently used instruments to assess HRQOL; analyzed specific facets and determinants of HRQOL (such as sex, tumor location and histological classification, depression, and cognitive function), as well as the association between HRQOL and survival; and appraised the effects of new treatments on HRQOL in patients with HGG from randomized controlled trials. Furthermore, we detected broadly existing problems and many contradictory outcomes and gave some proper interpretation and suggestions regarding them.
摘要
健康相关生活质量（HRQOL）在癌症研究中已成为一个越来越重要的终点指标；然而，与其他肿瘤患者相比，对高级别胶质瘤（HGG）患者的HRQOL研究较少。由于HGG的特殊位置和较差的预后，研究HGG患者的HRQOL比研究其他肿瘤患者更为重要且困难；此外，HGG患者的HRQOL研究与其他肿瘤患者的研究也有所不同。在本综述中，我们识别并比较了评估HRQOL最常用的工具；分析了HRQOL的具体方面和决定因素（如性别、肿瘤位置和组织学分类、抑郁和认知功能），以及HRQOL与生存之间的关联；并从随机对照试验评估了新治疗方法对HGG患者HRQOL的影响。此外，我们发现了广泛存在的问题和许多相互矛盾的结果，并对其进行了适当的解释和建议。
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