术后运动功能和处理速度可预测慢性期胶质母细胞瘤患者的生活质量。

Postsurgical motor function and processing speed as predictors of quality of life in patients with chronic-phase glioblastoma.

机构信息

Department of Occupational Therapy, Faculty of Health Science, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

Department of Neurosurgery, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

出版信息

Acta Neurochir (Wien). 2024 Aug 31;166(1):357. doi: 10.1007/s00701-024-06245-1.

DOI:10.1007/s00701-024-06245-1

PMID:39215803

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11365834/

Abstract

PURPOSE

Patients with glioblastomas (GBMs) have poor prognosis despite various treatments; therefore, attention should be paid to maintaining the quality of survival. Neurocognitive deficits can affect the quality of life (QOL) in patients with GBM. Most studies concerning QOL and neurocognitive functions have demonstrated a relationship between QOL and self-reported neurocognitive decline, although this method does not accurately reflect damaged functional domains. Therefore, this study aimed to clarify the neurocognitive functions that influence the QOL in patients with GBMs using an objective assessment of neurocognitive functions.

METHODS

Data from 40 patients newly diagnosed with GBMs were analyzed. All patients completed the assessment of QOL and various neurological and neurocognitive functions including general cognitive function, processing speed, attention, memory, emotion recognition, social cognition, visuospatial cognition, verbal fluency, language, motor function, sensation, and visual field at 6 months postoperatively. QOL was assessed using the 36-Item Short Form Survey (SF-36). In the SF-36, the physical, mental, and role and social component summary (PCS, MCS, and RCS, respectively) scores were calculated. Multiple logistic regression analyses and chi-square tests were used to evaluate the association between SF-36 scores and neurocognitive functions.

RESULTS

The MCS was maintained, while the PCS and RCS scores were significantly lower in patients with GBMs than in healthy controls (p = 0.0040 and p < 0.0001, respectively). Among several neurocognitive functions, motor function and processing speed were significantly correlated with PCS and RCS scores, respectively (p = 0.0048 and p = 0.030, respectively). Patients who maintained their RCS or PCS scores had a higher probability of preserving motor function or processing speed than those with low RCS or PCS scores (p = 0.0026).

CONCLUSIONS

Motor function and processing speed may be predictors of QOL in patients with GBMs.

摘要

目的

尽管采用了各种治疗方法，胶质母细胞瘤（GBM）患者的预后仍然很差；因此，应注意维持生存质量。神经认知缺陷会影响 GBM 患者的生活质量（QOL）。大多数关于 QOL 和神经认知功能的研究表明，QOL 与自我报告的神经认知下降之间存在关系，尽管这种方法不能准确反映受损的功能领域。因此，本研究旨在使用神经认知功能的客观评估来阐明影响 GBM 患者 QOL 的神经认知功能。

方法

分析了 40 例新诊断为 GBM 的患者的数据。所有患者在术后 6 个月完成了 QOL 评估以及各种神经和神经认知功能评估，包括一般认知功能、处理速度、注意力、记忆、情绪识别、社会认知、视空间认知、言语流畅性、语言、运动功能、感觉和视野。使用 36 项简短健康调查问卷（SF-36）评估 QOL。在 SF-36 中，计算了生理、心理、角色和社会成分综合评分（PCS、MCS 和 RCS）。采用多因素逻辑回归分析和卡方检验评估 SF-36 评分与神经认知功能之间的关系。

结果

与健康对照组相比，GBM 患者的 MCS 保持不变，而 PCS 和 RCS 评分明显降低（p=0.0040 和 p<0.0001）。在几种神经认知功能中，运动功能和处理速度与 PCS 和 RCS 评分分别显著相关（p=0.0048 和 p=0.030）。与低 RCS 或 PCS 评分的患者相比，保持 RCS 或 PCS 评分的患者保持运动功能或处理速度的可能性更高（p=0.0026）。