Paton R C, Toh C-H
Department of Computer Science, University of Liverpool, Liverpool L69 3BX, UK.
Comp Funct Genomics. 2004;5(1):85-90. doi: 10.1002/cfg.360.
The purpose of this short article is to examine certain aspects of protein functionality with relation to some key organizing ideas. This is important from a computational viewpoint in order to take account of modelling both biological systems and knowledge of these systems. We look at some of the lexical dimensions of the function and how certain constructs can be related to underlying ideas. The pervasive computational metaphor is then discussed in relation to protein multifunctionality, and the specific case of von Willebrand factor as a 'smart' multifunctional protein is briefly considered. Some diagrammatic techniques are then introduced to better articulate protein function.
这篇短文的目的是探讨蛋白质功能的某些方面与一些关键组织理念的关系。从计算的角度来看，这很重要，以便在对生物系统及其相关知识进行建模时加以考虑。我们研究了功能的一些词汇维度，以及某些结构如何与潜在理念相关联。接着讨论了与蛋白质多功能性相关的普遍计算隐喻，并简要考虑了血管性血友病因子作为一种“智能”多功能蛋白质的具体案例。然后引入了一些图表技术，以更好地阐明蛋白质功能。
