Rau Aarathi R, Kini Hema, Pai Radha R, Shetty Ashok B
Department of Pathology, Kasturba Medical College, Mangalore, India.
Indian J Chest Dis Allied Sci. 2008 Jul-Sep;50(3):295-7.
Wegener's granulomatosis is a distinct clinico-pathological entity characterised by a triad of upper and lower respiratory disease and renal involvement, although atypical presentations can be seen. These patients characteristically have small vessel vasculitis and or granulomatous vasculitis and are usually anti-neutrophilic cytoplasmic antibody (ANCA) positive. We present a case of Wegener's granulomatosis that clinically mimicked a lung neoplasm with a paraneoplastic syndrome. Biopsy and histopathological evaluation of a readily accessible subcutaneous nodule showed small vessel vasculitis. Correlation with clinical data and ANCA positivity led to a definite diagnosis.
韦格纳肉芽肿病是一种独特的临床病理实体，其特征为上、下呼吸道疾病及肾脏受累三联征，不过也可见非典型表现。这些患者典型地患有小血管炎和/或肉芽肿性血管炎，且通常抗中性粒细胞胞浆抗体（ANCA）呈阳性。我们报告一例临床酷似伴有副肿瘤综合征的肺部肿瘤的韦格纳肉芽肿病病例。对一个易于获取的皮下结节进行活检及组织病理学评估显示为小血管炎。结合临床资料及ANCA阳性结果得出了明确诊断。
