Trojanowski John Q, Hendricks Joan C, Jedrziewski Kathryn, Johnson F Brad, Michel Kathryn E, Hess Rebecka S, Cancro Michael P, Sleeper Meg M, Pignolo Robert, Teff Karen L, Aguirre Gustavo D, Lee Virginia M-Y, Lawler Dennis F, Pack Allan I, Davies Peter F
School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Alzheimers Dement. 2008 Jan;4(1):1-5. doi: 10.1016/j.jalz.2007.09.007. Epub 2007 Dec 21.
At a symposium convened on March 8, 2007 by the Institute on Aging at the University of Pennsylvania, researchers from the University's Schools of Medicine and Veterinary Medicine explored the convergence of aging research emerging from the two schools. Studies in human patients, animal models, and companion animals have revealed different but complementary aspects of the aging process, ranging from fundamental biologic aspects of aging to the treatment of age-related diseases, both experimentally and in clinical practice. Participants concluded that neither animal nor human research alone will provide answers to most questions about the aging process. Instead, an optimal translational research model supports a bidirectional flow of information from animal models to clinical research.
2007年3月8日，宾夕法尼亚大学衰老研究所召开了一次研讨会，来自该校医学院和兽医学院的研究人员探讨了两校衰老研究的交叉点。对人类患者、动物模型和伴侣动物的研究揭示了衰老过程中不同但互补的方面，从衰老的基本生物学方面到实验和临床实践中与年龄相关疾病的治疗。与会者得出结论，仅靠动物研究或人体研究都无法回答大多数关于衰老过程的问题。相反，一个最佳的转化研究模型支持从动物模型到临床研究的双向信息流。
