Fillit Howard M, Simon Ely S, Doniger Glen M, Cummings Jeffrey L
Institute for the Study of Aging, Inc, New York, NY, USA.
Alzheimers Dement. 2008 Jan;4(1):14-21. doi: 10.1016/j.jalz.2007.09.008.
Early detection and diagnosis are critical to dementia care. However, many early cases remain undiagnosed as a result of the impracticality of neuropsychological testing, particularly in primary care. Mindstreams is an office-based computerized system for measuring cognitive function in multiple domains, with demonstrated validity, test-retest reliability, and sensitivity to treatment effects. This study evaluated its feasibility for assessment of the elderly.
Usability data were collected after each of 2,888 consecutive initial-visit testing sessions at the first 11 clinical centers to use Mindstreams. The chi(2) goodness-of-fit test was employed to determine whether patients and supervisors more often rated tests easy versus hard to use. Separate analyses were run for non-computer users, patients older than 75 years, and poor performers (< or =1 standard deviation on overall battery performance).
For all patients (n = 2,888; age, 64.7 +/- 18.2 years), 83% rated the tests easy to use (P < .001). Seventy-three percent of non-computer users, 70% of patients older than 75, and 69% of poor performers rated them easy to use (Ps < .001). Supervisor ratings and ease of understandability ratings were similar. For all patients, 76% of supervisor ratings indicated no patient frustration (P < .001). Seventy-eight percent of ratings for non-computer users, 76% for patients older than 75, and 74% for poor performers indicated no frustration (Ps < .001).
Mindstreams was easily employed, including in patients with considerable cognitive impairment, supporting its practicality for in-office cognitive assessment of the elderly. The availability of such valid and practical assessment suggests the feasibility of integrating the technology within a clinical algorithm for improved detection of cognitive decline.
早期发现和诊断对痴呆症护理至关重要。然而,由于神经心理学测试不切实际,尤其是在初级保健中,许多早期病例仍未得到诊断。Mindstreams是一个基于办公室的计算机化系统,用于测量多个领域的认知功能,具有已证实的有效性、重测信度和对治疗效果的敏感性。本研究评估了其用于评估老年人的可行性。
在最初使用Mindstreams的11个临床中心的2888次连续初诊测试会话结束后,收集了可用性数据。采用卡方拟合优度检验来确定患者和主管对测试易用性与难用性的评价频率是否更高。对非计算机用户、75岁以上患者以及表现较差者(总体测试表现低于或等于1个标准差)进行了单独分析。
对于所有患者(n = 2888;年龄,64.7±18.2岁),83%的患者认为测试易于使用(P <.001)。73%的非计算机用户、70%的75岁以上患者以及69%的表现较差者认为测试易于使用(P值均<.001)。主管的评价和易于理解程度的评价相似。对于所有患者,76%的主管评价表明患者没有感到沮丧(P <.001)。78%的非计算机用户评价、76%的75岁以上患者评价以及74%的表现较差者评价表明没有沮丧(P值均<.001)。
Mindstreams易于使用,包括对有相当认知障碍的患者,这支持了其在办公室对老年人进行认知评估的实用性。这种有效且实用的评估方法的可用性表明,将该技术整合到临床算法中以改善认知衰退检测是可行的。