The Turner Institute for Brain and Mental Health, Monash University, Clayton, Victoria, Australia.
Melbourne School of Psychological Sciences, University of Melbourne, Parkville, Victoria, Australia.
Sleep. 2021 Sep 13;44(9). doi: 10.1093/sleep/zsab097.
To examine if sleep symptomatology was associated with subjective cognitive concerns or objective cognitive performance in a dementia-free community-based sample.
A total of 1,421 middle-aged participants (mean ± standard deviation = 57 ± 7; 77% female) from the Healthy Brain Project completed the Pittsburgh Sleep Quality Index, Insomnia Severity Index, and Epworth Sleepiness Scale to measure sleep quality, insomnia symptom severity, and daytime sleepiness, respectively. Participants were classified as having no sleep symptomatology (normal scores on each sleep measure), moderate sleep symptomatology (abnormal scores on one sleep measure), or high sleep symptomatology (abnormal scores on at least two sleep measures), using established cutoff values. Analysis of covariance was used to compare objective cognitive function (Cogstate Brief Battery) and subjective cognitive concerns (Modified Cognitive Function Instrument) across groups.
Following adjustments for age, sex, education, mood, and vascular risk factors, persons classified as having high sleep symptomatology, versus none, displayed more subjective cognitive concerns (d = 0.24) but no differences in objective cognitive performance (d = 0.00-0.18). Subjective cognitive concerns modified the association between sleep symptomatology and psychomotor function. The strength of the relationship between high sleep symptomatology (versus none) and psychomotor function was significantly greater in persons with high as compared with low cognitive concerns (β ± SE = -0.37 ± 0.16; p = 0.02).
More severe sleep symptomatology was associated with greater subjective cognitive concerns. Persons reporting high levels of sleep symptomatology may be more likely to display poorer objective cognitive function in the presence of subjective cognitive concerns.
在无痴呆的社区样本中，研究睡眠症状是否与主观认知问题或客观认知表现有关。
共有 1421 名来自健康大脑项目的中年参与者（平均值±标准偏差=57±7；77%为女性）完成了匹兹堡睡眠质量指数、失眠严重程度指数和 Epworth 嗜睡量表，分别用于测量睡眠质量、失眠症状严重程度和白天嗜睡。使用既定的截断值，将参与者分为无睡眠症状（每项睡眠测量的正常分数）、中度睡眠症状（一项睡眠测量的异常分数）或高度睡眠症状（至少两项睡眠测量的异常分数）。采用协方差分析比较各组之间的客观认知功能（Cogstate 简短电池）和主观认知问题（改良认知功能仪器）。
在调整年龄、性别、教育、情绪和血管危险因素后，与无睡眠症状相比，被归类为高睡眠症状的人表现出更多的主观认知问题（d=0.24），但在客观认知表现方面没有差异（d=0.00-0.18）。主观认知问题改变了睡眠症状与精神运动功能之间的关联。与无认知问题相比，高认知问题人群中，高睡眠症状（与无睡眠症状相比）与精神运动功能之间的关系更强（β±SE=-0.37±0.16；p=0.02）。
更严重的睡眠症状与更大的主观认知问题有关。报告有高水平睡眠症状的人在存在主观认知问题时，更有可能表现出较差的客观认知功能。
