Neeb H, Ermer V, Stocker T, Shah N J
Institute of Neuroscience and Biophysics 3 - Medicine, Research Centre Jülich GmbH, 52425 Jülich, Germany.
Neuroimage. 2008 Sep 1;42(3):1094-109. doi: 10.1016/j.neuroimage.2008.03.060. Epub 2008 Apr 11.
Quantitative mapping of water content, especially in the human brain, has the potential to provide important information for the study and diagnosis of diseases associated with a focal or global change in tissue water homeostasis. In the current work, an imaging method for the precise and accurate quantification of tissue water content is presented. The method allows the acquisition of water content maps with voxel dimensions of 1x1x2 mm(3) and full brain coverage in less than 10 min on a standard clinical 1.5 T scanner. The precision was optimised for human brain imaging and possible sources of systematic error were carefully investigated, demonstrating the ability of the method to quantify water content with high accuracy and precision. The approach was validated in phantom experiments and quantitative cerebral water content maps of a group of 10 healthy volunteers were obtained.
定量绘制含水量图，尤其是在人脑方面，有可能为研究和诊断与组织水平衡的局灶性或全身性变化相关的疾病提供重要信息。在当前的工作中，提出了一种用于精确和准确量化组织含水量的成像方法。该方法能够在标准临床1.5T扫描仪上，在不到10分钟的时间内获取体素尺寸为1x1x2 mm³且覆盖全脑的含水量图。针对人脑成像对精度进行了优化，并仔细研究了可能的系统误差来源，证明了该方法能够高精度和高精确地量化含水量。该方法在体模实验中得到了验证，并获得了一组10名健康志愿者的定量脑含水量图。
