Li Wei, Baker Nicholas E
Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Fly (Austin). 2007 Sep-Oct;1(5):274-8. doi: 10.4161/fly.5247. Epub 2007 Sep 4.
Cell competition was first described in imaginal discs of genetically-mosaic Drosophila. In extreme cases, cell competition can replace entire compartments with the descendents of a single cell. We recently identified five genes that are required by wild-type epithelial cells to kill neighboring Minute cells during cell competition. These draper, wasp, phosphatidyl-serine receptor, MBC/DOCK180 and Rac1 genes, were each previously implicated in the engulfment of apoptotic corpses. The results draw attention to the active, killing role of engulfing cells during cell competition. Here we discuss the contributions of these engulfment genes to Minute competition in more detail, and compare Minute competition with competition between cells expressing different levels of Myc, or of Warts pathway genes. We also speculate about how cell interactions at clone boundaries may initiate cell competition.
细胞竞争最早是在基因嵌合的果蝇成虫盘上被描述的。在极端情况下，细胞竞争可以用单个细胞的后代取代整个细胞区室。我们最近鉴定出五个基因，野生型上皮细胞在细胞竞争过程中需要这些基因来杀死相邻的微小细胞。这些基因分别是Draper、Wasp、磷脂酰丝氨酸受体、MBC/DOCK180和Rac1，它们之前都与凋亡小体的吞噬作用有关。这些结果使人们关注到吞噬细胞在细胞竞争过程中的主动杀伤作用。在这里，我们更详细地讨论这些吞噬基因对微小细胞竞争的贡献，并将微小细胞竞争与表达不同水平Myc或疣途径基因的细胞之间的竞争进行比较。我们还推测克隆边界处的细胞相互作用可能如何引发细胞竞争。
