抗人白细胞抗原I类单克隆抗体（01.65）和N - N - 星形孢菌素对PHA激活的T淋巴细胞增殖反应的竞争作用。
Competitive effect of anti-HLA class I monoclonal antibody (01.65) and N-N-staurosporine on prolipherative response of PHA activated T-lymphocytes.
作者信息
Selvatici R, Orlando P, Rubini M, Balboni A, Balugani S, Gandini E
机构信息
Istituto di Genetica Medica, Università di Ferrara, Italy.
出版信息
Biochem Int. 1991 Jan;23(1):53-8.
N-N-Staurosporine (STAR) inhibits in a dose dependent manner Tritiated-Thymidine (3H-TdR) incorporation in phytohemagglutinin (PHA) activated Peripheral Blood Mononuclear Cells (PBMC) treated with anti-HLA class I monoclonal antibody (MAb) 01.65 and its effect results competitive with MAb 01.65. Cytosolic and particulate Protein Kinase C (PKC) have been studied. Only when PKC particulate activity is no more detectable, the effect of STAR on 3H-TdR incorporation is evident.
N-N-星孢菌素（STAR）以剂量依赖性方式抑制用抗HLA I类单克隆抗体（MAb）01.65处理的植物血凝素（PHA）激活的外周血单个核细胞（PBMC）中氚标记胸腺嘧啶核苷（3H-TdR）的掺入，其作用与MAb 01.65具有竞争性。已对细胞溶质和颗粒性蛋白激酶C（PKC）进行了研究。只有当PKC颗粒活性不再可检测到时，STAR对3H-TdR掺入的作用才明显。
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