Kober Benjamin J, Scheule Albertus M, Voth Vladimir, Deschner Norbert, Schmid Eckhard, Ziemer Gerhard
Division of Thoracic, Cardiac and Vascular Surgery, Tübingen University Hospital, Hoppe-Seyler-Strasse 3, D-72076 Tübingen, Germany.
Anesth Analg. 2008 Aug;107(2):406-9. doi: 10.1213/ane.0b013e31817e6043.
We report a 67-yr-old male after multiple surgical procedures for treatment of arterial occlusive disease who suffered an anaphylactic reaction after administration of aprotinin (Trasylol) prior to urgent coronary artery bypass surgery. The patient had been treated with aprotinin-containing fibrin sealant in 2004 and in 2007, 2 wk before coronary artery bypass surgery. The postoperative serologic screening revealed positive results for qualitative aprotinin-specific IgG, highly elevated quantitative aprotinin-specific IgG and moderately elevated aprotinin-specific IgE antibodies.
我们报告了一名67岁男性，该患者因动脉闭塞性疾病接受了多次外科手术治疗，在紧急冠状动脉搭桥手术前给予抑肽酶（特血乐）后发生过敏反应。该患者曾在2004年以及2007年冠状动脉搭桥手术前2周接受过含抑肽酶的纤维蛋白封闭剂治疗。术后血清学筛查显示，定性抑肽酶特异性IgG结果为阳性，定量抑肽酶特异性IgG高度升高，抑肽酶特异性IgE抗体中度升高。
