Chelidze K, Jgarkava M
Tbilisi State Medical University, Department of Internal Medicine.
Georgian Med News. 2008 Jun(159):27-30.
This article reviews the role of antibiotic therapy in the management of patients with acute infectious exacerbation of chronic obstructive pulmonary disease (COPD). Papers relevant to the issue are included in the review. Current antibiotic therapy of acute infectious exacerbation of COPD is directed at the most common pathogens, including Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis. Mild to moderate exacerbations of COPD are usually treated with broad-spectrum antibiotics such as doxycycline, trimethoprim-sulfamethoxazole and amoxicillin-clavulanate potassium. Treatment with augmented penicillins, fluoroquinolones, third-generation cephalosporins or aminoglycosides may be considered in patients with more severe exacerbations.
本文综述了抗生素治疗在慢性阻塞性肺疾病（COPD）急性感染加重期患者管理中的作用。与该问题相关的论文纳入了本综述。目前COPD急性感染加重期的抗生素治疗针对最常见的病原体，包括肺炎链球菌、流感嗜血杆菌和卡他莫拉菌。COPD的轻至中度加重通常用广谱抗生素治疗，如多西环素、甲氧苄啶-磺胺甲恶唑和阿莫西林-克拉维酸钾。对于更严重加重的患者，可考虑使用加酶青霉素、氟喹诺酮类、第三代头孢菌素或氨基糖苷类进行治疗。
