基于1,1-双（三甲基硅氧基）乙烯酮缩醛与异喹啉和喹啉的非对映选择性反应合成氮杂双环[3.3.1]壬酮
Synthesis of azoxabicyclo[3.3.1]nonanones based on diastereoselective reactions of 1,1-bis(trimethylsilyloxy)ketene acetals with isoquinolines and quinolines.
作者信息
Schmidt Andreas, Michalik Dirk, Rotzoll Sven, Ullah Ehsan, Fischer Christine, Reinke Helmut, Görls Helmar, Langer Peter
机构信息
Institut für Chemie, Universität Rostock, Rostock, Germany.
出版信息
Org Biomol Chem. 2008 Aug 7;6(15):2804-14. doi: 10.1039/b804139c. Epub 2008 Jun 12.
DOI:10.1039/b804139c
PMID:18633539
Abstract
Densely functionalized azoxabicyclo[3.3.1]nonanones were prepared by regio- and diastereoselective condensation of 1,1-bis(silyloxy)ketene acetals with isoquinolinium and quinolinium salts and subsequent regioselective and stereospecific iodolactonization.
摘要
通过1,1-双（硅氧基）乙烯酮缩醛与异喹啉鎓盐和喹啉鎓盐的区域和非对映选择性缩合以及随后的区域选择性和立体特异性碘内酯化反应，制备了高密度官能化的氮杂双环[3.3.1]壬酮。
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