[中枢性眼球运动障碍的药物治疗]

[Pharmacotherapy of central oculomotor disorders].

作者信息

Kalla R, Spiegel R, Wagner J, Rettinger N, Jahn K, Strupp M

机构信息

Neurologische Klinik, Klinikum Grosshadern Ludwig-Maximilians-Universität (LMU) München, Marchioninistr. 15, 81377, München.

出版信息

Nervenarzt. 2008 Dec;79(12):1377-8, 1380-2, 1384-5. doi: 10.1007/s00115-008-2516-0.

DOI:10.1007/s00115-008-2516-0

PMID:18633586

Abstract

Nystagmus causes blurred vision due to oscillopsia, as well as impaired balance. Depending on etiology, additional cerebellar and brain stem signs may occur. We present the current pharmacotherapy of the most common forms of central nystagmus: downbeat nystagmus (DBN), upbeat nystagmus (UBN), acquired pendular nystagmus (APN), and congenital nystagmus (CGN). Recommended medical therapies are aminopyridines (4-AP) for DBN and UBN, gabapentin and memantine for CGN and APN, and baclofen for periodic alternating nystagmus (PAN).

摘要

眼球震颤会因视振荡导致视力模糊，还会损害平衡。根据病因，可能会出现其他小脑和脑干体征。我们介绍了中枢性眼球震颤最常见类型的当前药物治疗方法：下跳性眼球震颤（DBN）、上跳性眼球震颤（UBN）、后天性摆动性眼球震颤（APN）和先天性眼球震颤（CGN）。推荐的药物治疗是：DBN和UBN使用氨基吡啶（4-AP），CGN和APN使用加巴喷丁和美金刚，周期性交替性眼球震颤（PAN）使用巴氯芬。