Jensen B N, Lisse I M, Gerstoft J, Borgeskov S, Skinhøj P
Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
AIDS. 1991 May;5(5):527-33. doi: 10.1097/00002030-199105000-00008.
Bronchoalveolar lavage (BAL) cell differentials and T-lymphocyte subpopulations were analysed in 95 HIV-infected patients with pulmonary symptoms to determine whether the type of cellular inflammatory response could be useful in diagnosis or as a prognostic marker. Patients with Pneumocystis carinii pneumonia (PCP) had more BAL fluid lymphocytes, mainly comprising CD8+ cells, and patients with bacterial infection had more neutrophils than other patients. Neither of these changes were mirrored in peripheral blood. Seven patients who died after their acute episode of PCP had significantly higher BAL fluid neutrophils than 53 patients with PCP who survived (P = 0.002). There seems to be correlation between BAL fluid neutrophilia, PCP and concomitant bacterial infection since four out of seven patients with a fatal outcome had coinfection with bacteria, whereas only one patient with PCP and bacterial coinfection survived (P = 0.0007).
对95例有肺部症状的HIV感染患者的支气管肺泡灌洗（BAL）细胞分类和T淋巴细胞亚群进行分析，以确定细胞炎症反应类型是否有助于诊断或作为预后标志物。卡氏肺孢子虫肺炎（PCP）患者的BAL液淋巴细胞更多，主要由CD8 +细胞组成，细菌感染患者的中性粒细胞比其他患者更多。外周血中均未出现这些变化。7例PCP急性发作后死亡的患者BAL液中性粒细胞明显高于53例存活的PCP患者（P = 0.002）。BAL液中性粒细胞增多、PCP和合并细菌感染之间似乎存在相关性，因为7例预后不良的患者中有4例合并细菌感染，而只有1例PCP合并细菌感染的患者存活（P = 0.0007）。
