Gałecki Piotr, Florkowski Antoni, Mrowicka Małgorzata, Pietras Tadeusz, Gałecka Elzbieta
Uniwersytet Medyczny w Łodzi, Klinika Psychiatrii Dorosłych.
Pol Merkur Lekarski. 2008 Jan;24(139):72-5.
Depressive disorder is still a rising and important problem in the modern world, it affects about 15% of the population. Present forms of treatment are effective in about 70% and require monthly therapy which sometimes causes side effects. Last decade studies paid attention to theories different to monoaminergic and to neurodegenerative changes mainly in the limbic system of hippocampus. In this article authors show a relationship between calcium ions, glutaminergic transduction and disfunction of hypothalamic-pituitary-adrenal (HPA) axis. They also take into account the activity of calcium dependent ATPase and its influence on overproduction of reactive oxygen species in the central neuron system (CNS). In the second part authors conclude that deregulation of calcium ions concentration in and out of cells and decreased activity of calcium dependent ATPase stimulate tricarboxylic acid cycle, oxidative phosphorilation. Mitochondria work faster and consume more oxygen. It correlates well with overproduction of reactive oxygen species (RFT). Above process results in neurons apoptosis and necrosis.
抑郁症在现代社会仍然是一个日益严重且重要的问题，它影响着约15%的人口。目前的治疗方法约70%有效，且需要每月进行治疗，有时会产生副作用。过去十年的研究关注了与单胺能不同的理论以及主要在海马体边缘系统的神经退行性变化。在本文中，作者展示了钙离子、谷氨酸能转导与下丘脑 - 垂体 - 肾上腺（HPA）轴功能障碍之间的关系。他们还考虑了钙依赖性ATP酶的活性及其对中枢神经系统（CNS）中活性氧过度产生的影响。在第二部分，作者得出结论，细胞内外钙离子浓度的失调以及钙依赖性ATP酶活性的降低会刺激三羧酸循环、氧化磷酸化。线粒体工作加快，消耗更多氧气。这与活性氧（RFT）的过度产生密切相关。上述过程导致神经元凋亡和坏死。
