Piccirillo J F, Lanza D C, Stasio E A, Moloy P J
Department of Surgery, Yale University School of Medicine, New Haven, Conn.
Arch Otolaryngol Head Neck Surg. 1991 Jul;117(7):800-2. doi: 10.1001/archotol.1991.01870190112024.
Histiocytic necrotizing lymphandenitis (HNL), or Kikuchi's disease, is a newly recognized disease of unknown origin that causes cervical lymphadenitis, usually in young women. Initially described in Japan, cases of HNL are being reported in the United States and other western countries with increasing frequency. Symptoms of HNL include tender cervical adenopathy, fever, weight loss, and night sweats. Laboratory studies reveal leukopenia with relative granulocytopenia and lymphocytosis. Lymph node biopsy reveals areas with frank cellular necrosis, karyorrhexis, and absence of plasma cells. The histologic features of HNL are distinctive but can be confused with those of lymphoma. We describe two cases of HNL and present recommendations for diagnosis and treatment.
组织细胞坏死性淋巴结炎（HNL），即菊池病，是一种新发现的病因不明的疾病，通常发生于年轻女性，可导致颈部淋巴结炎。该病最初在日本被描述，如今在美国和其他西方国家报告的病例越来越多。HNL的症状包括颈部淋巴结压痛、发热、体重减轻和盗汗。实验室检查显示白细胞减少伴相对粒细胞减少和淋巴细胞增多。淋巴结活检显示存在明显的细胞坏死、核碎裂，且无浆细胞。HNL的组织学特征独特，但可能与淋巴瘤的特征相混淆。我们描述了两例HNL病例，并提出了诊断和治疗建议。
